TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Prog Cardiovasc Dis. 2019 Jul-Aug;62(4):298-302. doi: 10.1016/j.pcad.2019.07.003. Epub 2019 Aug 1.
The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals.
2 型糖尿病（T2DM）的患病率已达到流行程度。T2DM 常导致大血管和/或微血管病理改变，从而增加心肌梗死、心力衰竭、中风、肾衰竭和生存率降低的风险。本文描述了 T2DM、心力衰竭和肾功能障碍之间的重要相互作用，形成恶性循环。中断这些循环代表了重要的治疗目标。
