Klausen N O, Juhl O, Sørensen J, Ferguson A H, Neumann P B
Department of Anaesthesia, Aalborg City and County Hospital, Denmark.
Acta Anaesthesiol Scand. 1988 Jul;32(5):409-12. doi: 10.1111/j.1399-6576.1988.tb02756.x.
Forty patients, scheduled for elective surgery in a thoracic and vascular surgical unit, were anaesthetized by a total intravenous anaesthesia technique using midazolam and fentanyl. Subsequent reversal of anaesthesia by the specific benzodiazepine antagonist flumazenil was evaluated in a double-blind trial. The patients were observed in the recovery room postoperatively until the next morning, and their recovery was repeatedly evaluated during the first 240 min after anaesthesia. Six patients in the placebo group required an oral airway or an endotracheal tube during the first hours of recovery, whereas none who received flumazenil did. The respiratory rate was significantly higher after flumazenil than placebo during the first 4 h postoperatively (Anova, P less than 0.01). Blood pressure and heart rate were not different between the two groups. The degree of sedation, orientation in time and space and the ability to cooperate were significantly superior after flumazenil than placebo (Anova, P less than 0.01). Some degree of resedation was observed in both groups, affecting 95% of the patients who received flumazenil against 30% after placebo (Mann-Whitney, P less than 0.05). No adverse reactions attributable to the use of flumazenil were encountered.
40名计划在胸血管外科进行择期手术的患者，采用咪达唑仑和芬太尼的全静脉麻醉技术进行麻醉。在一项双盲试验中评估了使用特异性苯二氮䓬拮抗剂氟马西尼随后逆转麻醉的效果。术后在恢复室观察患者直至次日早晨，并在麻醉后的最初240分钟内反复评估其恢复情况。安慰剂组中有6名患者在恢复的最初几个小时需要口咽气道或气管插管，而接受氟马西尼的患者中无人需要。术后最初4小时内，氟马西尼组的呼吸频率显著高于安慰剂组（方差分析，P<0.01）。两组之间的血压和心率无差异。氟马西尼组的镇静程度、时间和空间定向能力以及合作能力均显著优于安慰剂组（方差分析，P<0.01）。两组均观察到一定程度的再镇静，氟马西尼组95%的患者受到影响，而安慰剂组为30%（曼-惠特尼检验，P<0.05）。未遇到与使用氟马西尼相关的不良反应。
