Fennelly M E, Powell H, Galletly D C, Whitwam J G
Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Br J Anaesth. 1992 Mar;68(3):303-5. doi: 10.1093/bja/68.3.303.
Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained SpO2 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal SpO2. Arterial pressure, but not heart rate, also was greater in the flumazenil group in the recovery period.
20例接受心脏复律的患者使用咪达唑仑进行麻醉；其中10例接受氟马西尼治疗，用药后麻醉立即迅速逆转，这些患者在5 - 10分钟内呼吸空气时SpO2维持在95%以上。相比之下，安慰剂组患者仍有部分镇静，需要长达2小时的氧疗以维持正常的SpO2。在恢复期，氟马西尼组的动脉压升高，但心率未升高。
