维生素D2中毒剂量诱导的大鼠动脉硬化模型中的药物作用
Drug actions in rats with arteriosclerosis induced by toxic doses of vitamin D2.
作者信息
Baraka Y M, Bekemeier H
出版信息
Arch Toxicol Suppl. 1979(2):431-5. doi: 10.1007/978-3-642-67265-1_51.
The vascular response of isolated perfused hind legs from normal and arteriosclerotic rats to noradrenaline, ATP, PGF2 alpha and vasopressin was determined. The increase of perfusion pressure to noradrenaline and ATP was reduced and that to PGF2 alpha and vasopressin was enhanced in arteriosclerotic rats in comparison to normal animals. The results indicate that the reactivity of the vascular smooth muscle of isolated hind legs of arterioslerotic rats is not only quantitatively but also qualitatively different in comparison with normal rats.
测定了正常大鼠和动脉粥样硬化大鼠离体灌注后肢对去甲肾上腺素、ATP、前列腺素F2α和血管加压素的血管反应。与正常动物相比，动脉粥样硬化大鼠对去甲肾上腺素和ATP的灌注压升高降低，而对前列腺素F2α和血管加压素的灌注压升高增强。结果表明，与正常大鼠相比，动脉粥样硬化大鼠离体后肢血管平滑肌的反应性不仅在数量上而且在质量上都有所不同。
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