Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Rheumatology (Oxford). 2019 Oct 1;58(10):1715-1721. doi: 10.1093/rheumatology/kez286.
RA is a multifactorial autoimmune inflammatory disease characterized by synovitis, bone destruction and joint dysfunction that leads to shortening of lifespan and increased mortality rates. Currently available treatments of RA, by controlling various symptoms, only delay disease progression and have their own side effects. Consequently, there is the need for a novel therapeutic strategy that offers a more sustainable and biocompatible solution. Nanomedicine is a modern branch of nanobiotechnology that provides targeted therapy to inflamed rheumatic joints and thus prevents unwanted off-target side effects. This review highlights various nanotheranostic and nanotherapeutic strategies that are currently being used for the treatment of RA.
类风湿关节炎是一种多因素自身免疫性炎症性疾病，其特征为滑膜炎、骨破坏和关节功能障碍，从而导致寿命缩短和死亡率增加。目前，类风湿关节炎的治疗方法通过控制各种症状来延缓疾病进展，但都有其自身的副作用。因此，需要一种新的治疗策略，提供更可持续和生物相容性的解决方案。纳米医学是纳米生物技术的一个现代分支，它为发炎的风湿关节提供靶向治疗，从而防止不必要的脱靶副作用。本综述强调了目前用于治疗类风湿关节炎的各种纳米诊断和纳米治疗策略。
