“再植中毒血症”的实验研究。低温对断肢的影响。

An experimental study on "replantation toxemia". The effect of hypothermia on an amputated limb.

作者信息

Usui M, Ishii S, Muramatsu I, Takahata N

出版信息

J Hand Surg Am. 1978 Nov;3(6):589-96. doi: 10.1016/s0363-5023(78)80011-2.

Abstract

Hind legs of dogs were amputated at the middle of the thigh and preserved in three different conditions: in ice water, in a refrigerator, and at room temperature. After 6 or 12 hours of ischemia, recirculation was established. The survival rate of the animals was observed and measurement of limb edema, potassium, pH, and lactate in the blood was performed to study the effects of hypothermia on prevention of "replantation toxemia." Cooling of the amputated limb was effective for prevention of toxemia, and the cooling effect was greater in ice water than in a refrigerator. However, when cooled in ice water, some animals died due to toxemia when the time of ischemia was prolonged to 12 hours. In the dead animals, a close relationship was observed between the developement of toxemia and metabolic acidosis due to the increase in lactate.

摘要

将狗的后腿在大腿中部截肢，并在三种不同条件下保存：冰水中、冰箱中以及室温下。缺血6或12小时后，建立再灌注。观察动物的存活率，并对血液中的肢体水肿、钾、pH值和乳酸进行测量，以研究低温对预防“再植中毒血症”的影响。截肢肢体的冷却对预防中毒血症有效，且在冰水中的冷却效果比在冰箱中更好。然而，当在冰水中冷却时，当缺血时间延长至12小时，一些动物死于中毒血症。在死亡动物中，观察到中毒血症的发展与由于乳酸增加导致的代谢性酸中毒之间存在密切关系。