蛋鸡自然同时感染J亚群禽白血病病毒、马立克氏病病毒和网状内皮组织增殖症病毒时的组织学发现及病毒抗原分布
Histologic findings and viral antigen distribution in natural coinfection of layer hens with subgroup J avian leukosis virus, Marek's disease virus, and reticuloendotheliosis virus.
作者信息
Liu Hongmei, Ma Kui, Liu Miaomiao, Yang Chengcheng, Huang Xueting, Zhao Yu, Qi Kezong
机构信息
Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, Anhui, China.
出版信息
J Vet Diagn Invest. 2019 Sep;31(5):761-765. doi: 10.1177/1040638719868274. Epub 2019 Aug 5.
Abstract
We investigated the histologic findings and viral antigen distribution in 3 cases of natural coinfection of layer hens with subgroup J avian leukosis virus (ALV-J), Marek's disease virus (MDV), and reticuloendotheliosis virus (REV) in hens. At autopsy, diseased hens were found to have hepatosplenomegaly and thickened proventriculi, with white tumor nodules in the liver, spleen, lung, kidney, and ovary. Microscopically, most tissues had been infiltrated by neoplastic lymphocytes; the spleen, lung, proventriculus, heart, and liver had been infiltrated by both neoplastic lymphocytes and myeloblastic cells and/or primitive reticular cells. Fluorescence multiplex immunohistochemistry staining revealed ALV-J, MDV, and REV antigens co-expressed in the same tissue, even the same cell.
摘要
我们调查了3例蛋鸡自然感染J亚群禽白血病病毒（ALV-J）、马立克氏病病毒（MDV）和网状内皮组织增生症病毒（REV）的组织学发现及病毒抗原分布情况。尸检时，患病母鸡出现肝脾肿大和腺胃增厚，肝脏、脾脏、肺、肾和卵巢有白色肿瘤结节。显微镜下，大多数组织被肿瘤性淋巴细胞浸润；脾脏、肺、腺胃、心脏和肝脏被肿瘤性淋巴细胞以及成髓细胞和/或原始网状细胞浸润。荧光多重免疫组织化学染色显示，ALV-J、MDV和REV抗原在同一组织甚至同一细胞中共表达。
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