Department of Cardiology, Virginia Commonwealth University Health System, PO Box 980053, Richmond, VA 23235, USA.
Department of Electrophysiology, Virginia Commonwealth University Health System, PO Box 980053, Richmond, VA 23235, USA.
Med Clin North Am. 2019 Sep;103(5):821-834. doi: 10.1016/j.mcna.2019.05.004. Epub 2019 Jul 6.
The narrow therapeutic window of antiarrhythmic drugs makes their use clinically challenging. A solid understanding of the mechanisms of arrhythmias and how antiarrhythmics affect these mechanisms is only a preliminary step in their appropriate selection. Clinical factors, side-effect profiles, and proarrhythmic risks are more important than the cellular mechanisms of actions in drug selection and monitoring. This article provides a simplified approach to understanding cellular mechanisms and provides a practical approach to the selection and use of this important class of medications.
抗心律失常药物的治疗窗狭窄，使其在临床上的应用具有挑战性。深入了解心律失常的机制以及抗心律失常药物如何影响这些机制，只是正确选择药物的初步步骤。在药物选择和监测中，临床因素、副作用特征和致心律失常风险比药物作用的细胞机制更为重要。本文提供了一种简化理解细胞机制的方法，并提供了一种实用的方法来选择和使用这一重要类别的药物。
