环己烷三酮，新型膜活性抗菌剂。
Cyclohexane triones, novel membrane-active antibacterial agents.
作者信息
Lloyd W J, Broadhurst A V, Hall M J, Andrews K J, Barber W E, Wong-Kai-In P
机构信息
Roche Products Limited, Welwyn Garden City, Hertfordshire, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):814-8. doi: 10.1128/AAC.32.6.814.
Abstract
The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophilic substances into bacteria. Unlike cationic detergents, such as chlorhexidine, they did not cause disruption of the bacterial cytoplasmic membrane over a short time period. The most potent antibacterial cyclohexane trione studied had a reduced ability to inhibit solute transport in comparison with certain less active analogs. Cyclohexane triones may express more than a single type of antibacterial effect.
摘要
环己烷三酮是一类新型合成抗菌剂，对革兰氏阳性菌、流感嗜血杆菌和耻垢分枝杆菌具有活性。一般来说，这些化合物的行为方式与六氯酚相似，可抑制低分子量亲水性物质向细菌内的转运。与阳离子洗涤剂（如洗必泰）不同，它们在短时间内不会导致细菌细胞质膜破裂。与某些活性较低的类似物相比，所研究的最有效的抗菌环己烷三酮抑制溶质转运的能力有所降低。环己烷三酮可能表现出不止一种类型的抗菌作用。
相似文献
1
Cyclohexane triones, novel membrane-active antibacterial agents.环己烷三酮，新型膜活性抗菌剂。
Antimicrob Agents Chemother. 1988 Jun;32(6):814-8. doi: 10.1128/AAC.32.6.814.
2
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety.含有顺式或反式环己基部分的新型氟喹诺酮类化合物的合成与抗菌活性。
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7688-92. doi: 10.1016/j.bmcl.2012.09.106. Epub 2012 Oct 5.
3
[Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1997)].[1997年下呼吸道感染性疾病患者分离出的细菌对抗生素的敏感性]
Jpn J Antibiot. 1999 May;52(5):353-97.
4
[Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1994)].[1994年呼吸道传染病患者分离出的细菌对抗生素的敏感性]
Jpn J Antibiot. 1996 May;49(5):419-55.
5
Synthesis and antibacterial activity of novel enolphosphate derivatives.新型烯膦酸酯衍生物的合成与抗菌活性。
Bioorg Chem. 2010 Oct;38(5):218-23. doi: 10.1016/j.bioorg.2010.06.006. Epub 2010 Jul 6.
6
Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics.铜绿假单胞菌增加生物膜生长的金黄色葡萄球菌对膜靶向防腐剂和抗生素的敏感性。
mBio. 2019 Jul 30;10(4):e01501-19. doi: 10.1128/mBio.01501-19.
7
Anthra[1,2-][1,2,3]triazine-4,7,12(3)-triones as a New Class of Antistaphylococcal Agents: Synthesis and Biological Evaluation.蒽[1,2-][1,2,3]三嗪-4,7,12(3)-三酮类化合物作为一类新型抗葡萄球菌药物：合成与生物评价。
Molecules. 2019 Dec 13;24(24):4581. doi: 10.3390/molecules24244581.
8
Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.一种对金黄色葡萄球菌和铜绿假单胞菌有效的新型抗菌化合物作用模式的阐明
PLoS One. 2016 May 11;11(5):e0155139. doi: 10.1371/journal.pone.0155139. eCollection 2016.
9
Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo.替比培南匹伐酯片（一种新型口服碳青霉烯制剂）对多种病原菌的体内外抗菌特性
Molecules. 2016 Jan 6;21(1):62. doi: 10.3390/molecules21010062.
10
Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.源自MSI-78的膜活性十二肽的抗菌特性。
Biochim Biophys Acta. 2015 May;1848(5):1139-46. doi: 10.1016/j.bbamem.2015.02.001. Epub 2015 Feb 10.
引用本文的文献
1
The effect of disinfectants and antiseptics on co- and cross-selection of resistance to antibiotics in aquatic environments and wastewater treatment plants.消毒剂和防腐剂对水生环境及污水处理厂中抗生素耐药性的共同选择和交叉选择的影响。
Front Microbiol. 2022 Dec 13;13:1050558. doi: 10.3389/fmicb.2022.1050558. eCollection 2022.
2
Chemical profiling, in vitro antioxidant, membrane stabilizing and antimicrobial properties of wild growing Murraya paniculata from Amarkantak (M.P.).野生生长于马哈拉施特拉邦阿玛塔克（M.P.）的芸香属植物麻疯树的化学成分分析、体外抗氧化、膜稳定和抗菌特性。
Sci Rep. 2021 May 7;11(1):9691. doi: 10.1038/s41598-021-87404-7.
3
Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming and multidrug resistant uropathogens isolated from patients with UTI syndrome.金合欢水提取物治疗尿路感染综合征患者分离的生物膜形成和耐多药尿路病原体的疗效。
Sci Rep. 2020 Jul 7;10(1):11125. doi: 10.1038/s41598-020-67732-w.
4
Enhancement of vitality and activity of a plant growth-promoting bacteria (PGPB) by atmospheric pressure non-thermal plasma.常压非热等离子体增强植物促生菌（PGPB）的活力和活性。
Sci Rep. 2019 Jan 31;9(1):1044. doi: 10.1038/s41598-018-38026-z.
5
Current and past strategies for bacterial culture in clinical microbiology.临床微生物学中细菌培养的当前及过往策略。
Clin Microbiol Rev. 2015 Jan;28(1):208-36. doi: 10.1128/CMR.00110-14.
本文引用的文献
1
Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.与阿拉磷相关的膦肽抗菌剂：设计、合成及构效关系
Antimicrob Agents Chemother. 1980 Dec;18(6):897-905. doi: 10.1128/AAC.18.6.897.
2
Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain.β-内酰胺类抗生素对铜绿假单胞菌靶酶的渗透作用：高敏突变株与其亲本菌株的比较
Antimicrob Agents Chemother. 1980 Jul;18(1):94-100. doi: 10.1128/AAC.18.1.94.
3
Soap bacteriostats.肥皂抑菌剂。
J Am Oil Chem Soc. 1968 May;45(5):345-50. doi: 10.1007/BF02667108.
4
Antimicrobial actions of hexachlorophene: cytological manifestations.六氯酚的抗菌作用：细胞学表现
J Bacteriol. 1971 Oct;108(1):482-91. doi: 10.1128/jb.108.1.482-491.1971.
5
Phosphonopeptides as antibacterial agents: mechanism of action of alaphosphin.膦肽类作为抗菌剂：阿拉磷的作用机制
Antimicrob Agents Chemother. 1979 May;15(5):696-705. doi: 10.1128/AAC.15.5.696.
6
Phosphonopeptides as antibacterial agents: rationale, chemistry, and structure-activity relationships.膦肽作为抗菌剂：原理、化学及构效关系
Antimicrob Agents Chemother. 1979 May;15(5):677-83. doi: 10.1128/AAC.15.5.677.
7
Comparison of the effects of two lipophilic acids, hexachlorophene and decanoate, on Bacillus subtilis.两种亲脂酸（六氯酚和癸酸盐）对枯草芽孢杆菌作用效果的比较。
Antimicrob Agents Chemother. 1977 Sep;12(3):357-67. doi: 10.1128/AAC.12.3.357.
8
Mutants of Bacillus megaterium resistant to uncouplers of oxidative phosphorylation.巨大芽孢杆菌对氧化磷酸化解偶联剂具有抗性的突变体。
J Biol Chem. 1977 Sep 10;252(17):5936-8.
9
The outer membrane of Gram-negative bacteria.革兰氏阴性菌的外膜。
Adv Microb Physiol. 1979;20:163-250. doi: 10.1016/s0065-2911(08)60208-8.
10
Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics.大肠杆菌外膜作为β-内酰胺类抗生素渗透屏障的功能。
Antimicrob Agents Chemother. 1977 Sep;12(3):368-72. doi: 10.1128/AAC.12.3.368.
Zotero 插件