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本文引用的文献

1
Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.与阿拉磷相关的膦肽抗菌剂：设计、合成及构效关系
Antimicrob Agents Chemother. 1980 Dec;18(6):897-905. doi: 10.1128/AAC.18.6.897.
2
Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain.β-内酰胺类抗生素对铜绿假单胞菌靶酶的渗透作用：高敏突变株与其亲本菌株的比较
Antimicrob Agents Chemother. 1980 Jul;18(1):94-100. doi: 10.1128/AAC.18.1.94.
3
Soap bacteriostats.肥皂抑菌剂。
J Am Oil Chem Soc. 1968 May;45(5):345-50. doi: 10.1007/BF02667108.
4
Antimicrobial actions of hexachlorophene: cytological manifestations.六氯酚的抗菌作用：细胞学表现
J Bacteriol. 1971 Oct;108(1):482-91. doi: 10.1128/jb.108.1.482-491.1971.
5
Phosphonopeptides as antibacterial agents: mechanism of action of alaphosphin.膦肽类作为抗菌剂：阿拉磷的作用机制
Antimicrob Agents Chemother. 1979 May;15(5):696-705. doi: 10.1128/AAC.15.5.696.
6
Phosphonopeptides as antibacterial agents: rationale, chemistry, and structure-activity relationships.膦肽作为抗菌剂：原理、化学及构效关系
Antimicrob Agents Chemother. 1979 May;15(5):677-83. doi: 10.1128/AAC.15.5.677.
7
Comparison of the effects of two lipophilic acids, hexachlorophene and decanoate, on Bacillus subtilis.两种亲脂酸（六氯酚和癸酸盐）对枯草芽孢杆菌作用效果的比较。
Antimicrob Agents Chemother. 1977 Sep;12(3):357-67. doi: 10.1128/AAC.12.3.357.
8
Mutants of Bacillus megaterium resistant to uncouplers of oxidative phosphorylation.巨大芽孢杆菌对氧化磷酸化解偶联剂具有抗性的突变体。
J Biol Chem. 1977 Sep 10;252(17):5936-8.
9
The outer membrane of Gram-negative bacteria.革兰氏阴性菌的外膜。
Adv Microb Physiol. 1979;20:163-250. doi: 10.1016/s0065-2911(08)60208-8.
10
Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics.大肠杆菌外膜作为β-内酰胺类抗生素渗透屏障的功能。
Antimicrob Agents Chemother. 1977 Sep;12(3):368-72. doi: 10.1128/AAC.12.3.368.

环己烷三酮，新型膜活性抗菌剂。

Cyclohexane triones, novel membrane-active antibacterial agents.

作者信息

Lloyd W J, Broadhurst A V, Hall M J, Andrews K J, Barber W E, Wong-Kai-In P

机构信息

Roche Products Limited, Welwyn Garden City, Hertfordshire, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1988 Jun;32(6):814-8. doi: 10.1128/AAC.32.6.814.

DOI:10.1128/AAC.32.6.814
PMID:3137860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172288/
Abstract

The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophilic substances into bacteria. Unlike cationic detergents, such as chlorhexidine, they did not cause disruption of the bacterial cytoplasmic membrane over a short time period. The most potent antibacterial cyclohexane trione studied had a reduced ability to inhibit solute transport in comparison with certain less active analogs. Cyclohexane triones may express more than a single type of antibacterial effect.

摘要

环己烷三酮是一类新型合成抗菌剂，对革兰氏阳性菌、流感嗜血杆菌和耻垢分枝杆菌具有活性。一般来说，这些化合物的行为方式与六氯酚相似，可抑制低分子量亲水性物质向细菌内的转运。与阳离子洗涤剂（如洗必泰）不同，它们在短时间内不会导致细菌细胞质膜破裂。与某些活性较低的类似物相比，所研究的最有效的抗菌环己烷三酮抑制溶质转运的能力有所降低。环己烷三酮可能表现出不止一种类型的抗菌作用。