Swentek Lourdes, Chung Dean, Ichii Hirohito
Department of Surgery, University of California, Irvine, CA 92868, USA.
Antioxidants (Basel). 2021 Apr 23;10(5):657. doi: 10.3390/antiox10050657.
Pancreatitis is pathologic inflammation of the pancreas characterized by acinar cell destruction and oxidative stress. Repeated pancreatic insults can result in the development of chronic pancreatitis, characterized by irreversible fibrosis of the pancreas and many secondary sequelae, ultimately leading to the loss of this important organ. We review acute pancreatitis, chronic pancreatitis, and pancreatitis-related complications. We take a close look at the pathophysiology with a focus on oxidative stress and how it contributes to the complications of the disease. We also take a deep dive into the evolution and current status of advanced therapies for management including dietary modification, antioxidant supplementation, and nuclear factor erythroid-2-related factor 2-Kelch-like ECH-associated protein 1(Nrf2-keap1) pathway activation. In addition, we discuss the surgeries aimed at managing pain and preventing further endocrine dysfunction, such as total pancreatectomy with islet auto-transplantation.
胰腺炎是胰腺的病理性炎症，其特征为腺泡细胞破坏和氧化应激。反复的胰腺损伤可导致慢性胰腺炎的发生，其特征是胰腺不可逆纤维化及许多继发性后遗症，最终导致这个重要器官功能丧失。我们综述了急性胰腺炎、慢性胰腺炎及胰腺炎相关并发症。我们深入研究了病理生理学，重点关注氧化应激及其如何导致该疾病的并发症。我们还深入探讨了包括饮食调整、补充抗氧化剂以及激活核因子红细胞2相关因子2- Kelch样ECH相关蛋白1（Nrf2-keap1）通路等在内的先进治疗方法的发展历程和现状。此外，我们讨论了旨在控制疼痛和预防进一步内分泌功能障碍的手术，如全胰切除术加胰岛自体移植术。
