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茶树油对白内障超声乳化术后干眼治疗的效果:一项随机临床试验。

The effect of tea tree oil on dry eye treatment after phacoemulsification cataract surgery: A randomized clinical trial.

作者信息

Mohammadpour Mehrdad, Maleki Siamak, Khorrami-Nejad Masoud

机构信息

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Eur J Ophthalmol. 2020 Nov;30(6):1314-1319. doi: 10.1177/1120672119867642. Epub 2019 Aug 5.

Abstract

PURPOSE

To evaluate the effect of eyelid scrubbing with eye shampoo containing tea tree oil on dry eye disease following phacoemulsification cataract surgery.

METHODS

This prospective triple-blinded randomized clinical trial was performed on 62 eyes of 62 patients. Patients were randomly assigned to two groups-(1) treatment group: for 33 patients in the treatment group, artificial tears, topical steroid drops, and eye shampoos with tea tree oil and (2) for 29 patients in the control group, artificial tears, topical steroids, and eye shampoos without tea tree oil were used. In the first and second (after 1 month) follow-up visits, microscopic examination, refraction, corrected distance visual acuity, the ocular surface disease index score (by the questionnaire), Schirmer test, tear break-up time test, and osmolarity of tears (by TearLab) were recorded in treatment and control groups.

RESULTS

The mean age of patients was 66.37 ± 8.83 (range: 37-82) years, of which 49 (79%) were female and 13 (21%) were male. The results showed a significant improvement in tear break-up time test, corrected distance visual acuity, osmolarity, and ocular surface disease index score in both groups ( < 0.05). However, the number of decreases significantly only in the treatment group after treatment ( <0.001). Tear break-up time, osmolarity, and ocular surface disease index scores in the treatment group were significantly better than the control group ( < 0.05). However, there was no significant difference between the two groups in the pre- and post-Schirmer test results ( > 0.05).

CONCLUSION

Eyelid scrubbing with eye shampoo containing tea tree oil is recommended for dry eye treatment after cataract surgery, especially decrease in the number of .

摘要

目的

评估使用含茶树油的洗眼液进行眼睑清洁对白内障超声乳化术后干眼症的影响。

方法

对62例患者的62只眼进行了这项前瞻性三盲随机临床试验。患者被随机分为两组:(1)治疗组:治疗组的33例患者使用人工泪液、局部类固醇滴眼液以及含茶树油的洗眼液;(2)对照组:对照组的29例患者使用人工泪液、局部类固醇以及不含茶树油的洗眼液。在首次和第二次(1个月后)随访中,记录治疗组和对照组的显微镜检查、验光、矫正远视力、眼表疾病指数评分(通过问卷)、泪液分泌试验、泪膜破裂时间试验以及泪液渗透压(通过TearLab)。

结果

患者的平均年龄为66.37±8.83(范围:37 - 82)岁,其中49例(79%)为女性,13例(21%)为男性。结果显示两组的泪膜破裂时间试验、矫正远视力、渗透压以及眼表疾病指数评分均有显著改善(P<0.05)。然而,仅治疗组在治疗后数量显著减少(P<0.001)。治疗组的泪膜破裂时间、渗透压以及眼表疾病指数评分显著优于对照组(P<0.05)。然而,两组泪液分泌试验前后结果无显著差异(P>0.05)。

结论

建议使用含茶树油的洗眼液进行眼睑清洁以治疗白内障术后干眼症,尤其是减少数量。

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