From the Eye Research Center, Mashhad University of Medical Sciences (S.Z.G., G.Z.), and Department of Statistics, Ferdowsi University of Mashhad (M.J.N.), Mashhad, Iran.
From the Eye Research Center, Mashhad University of Medical Sciences (S.Z.G., G.Z.), and Department of Statistics, Ferdowsi University of Mashhad (M.J.N.), Mashhad, Iran.
Am J Ophthalmol. 2021 Sep;229:45-51. doi: 10.1016/j.ajo.2021.04.009. Epub 2021 Apr 24.
This study is aimed at comparing the effects of tea tree oil (TTO) shampoo with regular eyelid shampoo on the treatment of meibomian gland dysfunction (MGD) signs and symptoms.
Double-masked randomized clinical trial METHODOLOGY: Forty patients with MGD were treated by daily eyelid scrubbing with TTO shampoo in one eye and regular eyelid shampoo in the other one. Before treatment and then after 1 and 3 months, the effect on ocular surface symptoms, tear production and stability, and conjunctival and eyelid signs of the 2 eyes were compared.
Plugging and capping of meibomian gland orifices, foamy tear, glands expressibility, 5-Item Dry Eye Questionnaire score (DEQ5), and tear breakup time were improved more significantly in TTO shampoo-treated eyes (capping P = .050, plugging and glands expressibility P = .001, others P < .001). In spite of improvement in both eyes, scores of meibum quality, conjunctival hyperemia, corneal and conjunctival staining, and Schirmer1 test value showed no statistically significant difference between the eyes (P = .06, .187, .192, .19, respectively). Moreover, eyelid margin telangiectasia resolved only in TTO shampoo-treated eyes (P < .001). Trichiasis and distichiasis changed in neither group (P > .99). Furthermore, ocular surface irritation during scrubbing was more common with TTO shampoo (P = .002).
TTO shampoo was found to be more efficient than regular eyelid shampoo in controlling MGD signs and symptoms although ocular surface irritation during its application was more frequent.
本研究旨在比较茶树油（TTO）洗发水和常规眼睑清洁剂治疗睑板腺功能障碍（MGD）的效果。
双盲随机临床试验。
40 例 MGD 患者每天用 TTO 洗发水擦洗一只眼，用常规眼睑清洁剂擦洗另一只眼。在治疗前和治疗后 1 个月和 3 个月，比较双眼的眼表症状、泪液产生和稳定性以及结膜和眼睑体征的改善情况。
TTO 洗发水治疗组的睑板腺口堵塞和闭塞、泡沫状泪液、腺体可挤出性、干眼五项问卷评分（DEQ5）和泪膜破裂时间均有显著改善（堵塞 P=0.050，阻塞和腺体可挤出性 P=0.001，其他 P<0.001）。尽管双眼均有改善，但睑脂质量、结膜充血、角膜和结膜染色以及 Schirmer1 试验值的评分在双眼之间无统计学差异（P=0.06，0.187，0.192，0.19，分别）。此外，TTO 洗发水治疗组的眼睑缘毛细血管扩张仅得到缓解（P<0.001）。无论是在 TTO 洗发水治疗组还是常规眼睑清洁剂治疗组，倒睫和双行睫均未发生变化（P>0.99）。此外，TTO 洗发水在擦洗过程中引起的眼表刺激更为常见（P=0.002）。
尽管 TTO 洗发水在应用过程中会引起更频繁的眼表刺激，但与常规眼睑清洁剂相比，TTO 洗发水在控制 MGD 体征和症状方面更为有效。
