Agawa Shuhei, Futagami Seiji, Yamawaki Hiroshi, Ikeda Go, Noda Hiroto, Kirita Kumiko, Higuchi Kazutoshi, Murakami Makoto, Kodaka Yasuhiro, Ueki Nobue, Akamizu Takashi, Iwakiri Katsuhiko
Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
The First Department of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
J Clin Biochem Nutr. 2019 Jul;65(1):65-70. doi: 10.3164/jcbn.18-111. Epub 2019 May 18.
To determine whether serum acylated ghrelin levels were associated with anxiety, clinical symptoms, depressive status, quality of life, gastric motility and endoscopic findings based on Kyoto classification in functional dyspepsia (FD) patients.
We enrolled three groups, FD patients ( = 15) with high levels of acylated ghrelin, FD patients ( = 33) with normal levels of acylated ghrelin and FD patients ( = 35) with low levels of acylated ghrelin. There was no significant differences in the positivity of infection among the three groups. Clinical symptoms were evaluated by Gastrointestinal Symptom Rating Scale (GSRS) and FD symptoms based on Rome III classification. Acylated ghrelin levels were measured by ELISA methods. Depressive status, anxiety, sleep disturbance were respectively asscessed by Self-rating questionnaire for depression (SRQ-D) score, STAI-state/-trait, Pittsburgh sleep quality index (PSQI) scores. Endoscopic findings were evaluated based on Kyoto classification.
Body Mass Index (BMI) in FD patients with low levels of acylated ghrelin was significantly higher (<0.001 and = 0.008, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. SRQ-D scores in FD patients with low levels of acylated ghrelin was significantly lower ( = 0.008 and <0.001, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. Scoring of gastric atrophy, intestinal metaplasia, xanthoma and mucus based on Kyoto classification in FD patients with low levels of acylated ghrelin were significantly higher (<0.001, = 0.0077, = 0.036 and = 0.0063, respectively) compared to those in FD patients with more than low levels of acylated ghrelin.
Acylated ghrelin levels were associated with BMI, depressive status, and endoscopic findings based on Kyoto classification in FD patients.
基于京都分类法，确定功能性消化不良（FD）患者血清酰基化胃饥饿素水平是否与焦虑、临床症状、抑郁状态、生活质量、胃动力及内镜检查结果相关。
我们纳入了三组患者，酰基化胃饥饿素水平高的FD患者（n = 15）、酰基化胃饥饿素水平正常的FD患者（n = 33）以及酰基化胃饥饿素水平低的FD患者（n = 35）。三组患者中幽门螺杆菌感染阳性率无显著差异。采用胃肠道症状评定量表（GSRS）及基于罗马Ⅲ分类的FD症状评估临床症状。采用酶联免疫吸附测定（ELISA）法检测酰基化胃饥饿素水平。分别通过抑郁自评问卷（SRQ-D）评分、状态-特质焦虑问卷（STAI）、匹兹堡睡眠质量指数（PSQI）评分评估抑郁状态、焦虑及睡眠障碍情况。基于京都分类法评估内镜检查结果。
与酰基化胃饥饿素水平高和正常的FD患者相比，酰基化胃饥饿素水平低的FD患者的体重指数（BMI）显著更高（分别为P < 0.001和P = 0.008）。与酰基化胃饥饿素水平高和正常的FD患者相比，酰基化胃饥饿素水平低的FD患者的SRQ-D评分显著更低（分别为P = 0.008和P < 0.001）。与酰基化胃饥饿素水平不低的FD患者相比，酰基化胃饥饿素水平低的FD患者基于京都分类法的胃萎缩、肠化生、胃黄色瘤及黏液评分显著更高（分别为P < 0.001、P = 0.0077、P = 0.036和P = 0.0063）。
在FD患者中，酰基化胃饥饿素水平与BMI、抑郁状态及基于京都分类法的内镜检查结果相关。
