A single nucleotide polymorphism in is associated with endoscopic grading in Kyoto classification of gastritis.

The risk allele of a single nucleotide polymorphism (SNP) rs2294008 in the () gene is strongly associated with gastric cancer. Although the Kyoto classification score is believed to be an indicator of gastric cancer risk, it lacks supporting genetic evidence. We investigated the effect of this risk allele of SNP on the Kyoto score. Participants without a history of gastric cancer or () eradication underwent esophagogastroduodenoscopy, evaluation, and SNP genotyping. The Kyoto score is the sum of scores obtained from endoscopy-based atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. The Kyoto score is novel in the light of scoring for gastritis. A total of 323 patients were enrolled (number of individuals with genotype CC: 52; CT: 140; TT: 131, average age: 50.1 years, male: 50.8%). The patient baseline characteristics including age, sex, body mass index, smoking, drinking, family history of gastric cancer, and status had no association with SNP. The Kyoto score was higher in T (CT or TT genotype; risk allele) carriers than in CC carriers. Atrophy, enlarged folds, and diffuse redness scores were higher in T allele carriers (risk allele) than in CC genotype individuals. In multivariate analysis, the Kyoto score was independently associated with SNP (OR: 1.30,  = 0.012). Thus, the Kyoto score was associated with a genetic predisposition.