Qiu Kaixin, Zhang Xiaojie, Wang Shuai, Li Chunyan, Wang Xin, Li Xuezhi, Wu Yili
Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions, Institute of Mental Health, Jining Medical University, Jining, China.
Front Cell Neurosci. 2019 Jul 17;13:328. doi: 10.3389/fncel.2019.00328. eCollection 2019.
Alzheimer's disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking in cells. Growing evidence indicates that TMP21 is dysregulated in AD, which plays a pivotal role in neuritic plaque formation. Therefore, we aim to review the dysregulation of TMP21 in AD, the role of TMP21 in neuritic plaque formation and underlying mechanisms. Moreover, the potential role of TMP21 in neurofibrillary tangle formation, synaptic impairment and neuronal loss is discussed. It will provide an outlook into the potential of regulating TMP21 as a therapeutic approach for AD treatment.
阿尔茨海默病（AD）是老年人中最常见的痴呆形式，其特征为进行性认知障碍。神经炎性斑块、神经原纤维缠结和神经元丢失是AD大脑中的主要神经病理学特征。TMP21是细胞内蛋白质运输的关键分子。越来越多的证据表明，TMP21在AD中表达失调，在神经炎性斑块形成中起关键作用。因此，我们旨在综述TMP21在AD中的失调情况、TMP21在神经炎性斑块形成中的作用及其潜在机制。此外，还讨论了TMP21在神经原纤维缠结形成、突触损伤和神经元丢失中的潜在作用。这将为将调节TMP21作为AD治疗的一种治疗方法的潜力提供展望。
