Wang Qinqin, Cao Fei, Wu Yili
Shandong Collaborative Innovation Center for Diagnosis, Treatment & Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Front Aging Neurosci. 2021 Aug 17;13:713201. doi: 10.3389/fnagi.2021.713201. eCollection 2021.
Orexinergic system consisting of orexins and orexin receptors plays an essential role in regulating sleep-wake states, whereas sleep disruption is a common symptom of a number of neurodegenerative diseases. Emerging evidence reveals that the orexinergic system is disturbed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and multiple sclerosis (MS), whereas the dysregulation of orexins and/or orexin receptors contributes to the pathogenesis of these diseases. In this review, we summarized advanced knowledge of the orexinergic system and its role in sleep, and reviewed the dysregulation of the orexinergic system and its role in the pathogenesis of AD, PD, HD, and MS. Moreover, the therapeutic potential of targeting the orexinergic system for the treatment of these diseases was discussed.
由食欲素和食欲素受体组成的食欲素能系统在调节睡眠-觉醒状态中起着至关重要的作用，而睡眠障碍是许多神经退行性疾病的常见症状。新出现的证据表明，在包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和多发性硬化症（MS）在内的各种神经退行性疾病中，食欲素能系统受到干扰，而食欲素和/或食欲素受体的失调促成了这些疾病的发病机制。在本综述中，我们总结了食欲素能系统的前沿知识及其在睡眠中的作用，并回顾了食欲素能系统的失调及其在AD、PD、HD和MS发病机制中的作用。此外，还讨论了针对食欲素能系统治疗这些疾病的潜在治疗价值。
