Ragonese Paolo, Fierro Brigida, Salemi Giuseppe, Randisi Giovanna, Buffa Daniela, D'Amelio Marco, Aloisio Antonella, Savettieri Giovanni
Dipartimento di Neurologia, Oftalmologia, Otorinolaringoiatria e Psichiatria, Università di Palermo, Italy.
J Neurol Sci. 2005 Sep 15;236(1-2):31-5. doi: 10.1016/j.jns.2005.04.012.
To investigate frequency and associated factors of post polio syndrome (PPS) in an Italian cohort of people with prior poliomyelitis.
We screened subjects admitted for poliomyelitis at the paediatric hospital of the University of Palermo during the time frame 1945-1960. Patients who developed PPS were identified through a structured questionnaire and a neurologic examination. PPS diagnosis was made according to specified diagnostic criteria. Frequency of PPS was calculated in the selected cohort of polio survivors. The association with the investigated risk factors (sex, age at onset of polio, extension and severity of polio, education, associated diseases, cigarette smoking, trauma, polio vaccination) was analysed by the calculation of the odds ratio.
Forty-eight participants met the adopted diagnostic criteria for PPS, giving a prevalence of 31.0%. The prevalence rate was significantly higher in women than in men (p=0.02). Logistic regression analyses revealed a significant inverse association with onset of poliomyelitis at over 12 months of age (OR 0.33; CI 0.14-0.79) a higher degree of education (OR 0.20; CI 0.07-0.79), and a significant association with the presence of other diseases (OR 9.86; CI 3.69-26.34).
In our survey one-third of patients with prior poliomyelitis had PPS. Higher age at onset of poliomyelitis is inversely associated with PPS. The association with other diseases may indicate that a chronic physical stress, particularly in already weak motor units, can contribute to the development of signs and symptoms of PPS. Our results also suggest the impact of socio-economic conditions on the risk of PPS.
调查意大利一组既往患过脊髓灰质炎人群中脊髓灰质炎后综合征（PPS）的发生率及相关因素。
我们筛查了1945年至1960年期间在巴勒莫大学儿科医院因脊髓灰质炎入院的患者。通过结构化问卷和神经系统检查来确定发生PPS的患者。PPS诊断依据特定的诊断标准进行。计算所选脊髓灰质炎幸存者队列中PPS的发生率。通过计算比值比来分析与所调查危险因素（性别、脊髓灰质炎发病年龄、脊髓灰质炎的范围和严重程度、教育程度、相关疾病、吸烟、创伤、脊髓灰质炎疫苗接种）之间的关联。
48名参与者符合所采用的PPS诊断标准，患病率为31.0%。女性患病率显著高于男性（p = 0.02）。逻辑回归分析显示，与12个月龄以上发生脊髓灰质炎存在显著负相关（比值比0.33；可信区间0.14 - 0.79），与较高教育程度存在显著负相关（比值比0.20；可信区间0.07 - 0.79），与存在其他疾病存在显著正相关（比值比9.86；可信区间3.69 - 26.34）。
在我们的调查中，三分之一的既往患过脊髓灰质炎的患者患有PPS。脊髓灰质炎发病年龄较大与PPS呈负相关。与其他疾病的关联可能表明，慢性身体应激，特别是在已经衰弱的运动单位中，可能促使PPS体征和症状的出现。我们的结果还表明社会经济状况对PPS风险的影响。
