伴有重链基因重排及单核细胞-巨噬细胞系证据的恶性组织细胞增生症。

Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.

作者信息

Kamesaki H, Koya M, Miwa H, Kita K, Doi S, Tatsumi E, Hatanaka M, Uchino H

机构信息

First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

出版信息

Cancer. 1988 Oct 1;62(7):1306-9. doi: 10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820620711>3.0.co;2-u.

DOI:10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820620711>3.0.co;2-u

PMID:3138020

Abstract

A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologic markers specific for other cell lineages, and germ line configuration of the immunoglobulin light chain gene and the T-cell receptor beta-chain gene. Its neoplastic nature was suggested by the single rearranged band of the immunoglobulin heavy chain gene.

摘要

报告了一例独特的恶性组织细胞增多症（MH）病例。其起源于单核细胞 - 巨噬细胞系统的依据为：高特异性髓系细胞标志物（My4、MCS2和细胞质溶菌酶）的表达、酸性磷酸酶和氟化钠敏感的α - 萘乙酸酯酶的弥漫性活性、缺乏其他细胞谱系特异性的免疫标志物，以及免疫球蛋白轻链基因和T细胞受体β链基因的种系构型。免疫球蛋白重链基因的单一条带重排提示了其肿瘤性质。