Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.

作者信息

Kamesaki H, Koya M, Miwa H, Kita K, Doi S, Tatsumi E, Hatanaka M, Uchino H

机构信息

First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

出版信息

Cancer. 1988 Oct 1;62(7):1306-9. doi: 10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820620711>3.0.co;2-u.

A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologic markers specific for other cell lineages, and germ line configuration of the immunoglobulin light chain gene and the T-cell receptor beta-chain gene. Its neoplastic nature was suggested by the single rearranged band of the immunoglobulin heavy chain gene.