非酒精性脂肪性肝病患儿和青少年维生素 D 水平的Meta 分析。
The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis.
机构信息
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China.
The Third Affiliated Hospital of Guangdong Medical University (Longjiang Hospital of Shunde District), Foshan 528318, China.
出版信息
Biomed Res Int. 2019 Jul 14;2019:7643542. doi: 10.1155/2019/7643542. eCollection 2019.
BACKGROUND
The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group.
METHODS
Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases. The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI). Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots.
RESULTS
Eight articles were included in this meta-analysis. A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, < 0.01). Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups.
CONCLUSIONS
Low vitamin D levels were associated with NAFLD in children and adolescents.
背景
维生素 D 水平与非酒精性脂肪性肝病（NAFLD）之间的关系尚未在儿童和青少年中进行研究。我们对已发表的观察性研究进行了荟萃分析，以评估该年龄段血清 25-羟维生素 D [25(OH)D]水平与 NAFLD 之间的这种关联。
方法
在 2018 年 5 月 20 日之前，我们从以下电子数据库中确定了相关研究：PubMed、Cochrane 图书馆、Embase 和中国 CNKI 数据库。使用纽卡斯尔-渥太华量表评估纳入研究的质量，并使用标准化均数差（SMD）和 95%置信区间（CI）来估计维生素 D 水平与 NAFLD 之间的关联。使用亚组和敏感性分析来确定异质性的来源，并使用漏斗图评估发表偏倚。
结果
共有 8 篇文章纳入本荟萃分析。儿童和青少年中低 25(OH)D 水平与 NAFLD 之间存在显著差异（SMD=-0.59，95%CI=-0.98，-0.20， < 0.01）。亚组分析显示，在研究类型、地理位置、BMI 和年龄亚组中无差异。
结论
低维生素 D 水平与儿童和青少年的 NAFLD 有关。
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