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儿童非酒精性脂肪性肝病:肝脏及肝外并发症

Nonalcoholic Fatty Liver Disease in Children: Hepatic and Extrahepatic Complications.

作者信息

Selvakumar Praveen Kumar Conjeevaram, Kabbany Mohammad Nasser, Nobili Valerio, Alkhouri Naim

机构信息

Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA.

Liver Unit, IRCCS Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

出版信息

Pediatr Clin North Am. 2017 Jun;64(3):659-675. doi: 10.1016/j.pcl.2017.01.008.


DOI:10.1016/j.pcl.2017.01.008
PMID:28502444
Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic and extrahepatic complications of NAFLD in children.

摘要

非酒精性脂肪性肝病(NAFLD)被认为是代谢综合征的肝脏表现,已成为儿童和青少年中最常见的慢性肝病形式。NAFLD的组织学谱范围广泛,从相对良性的单纯性脂肪变性形式到侵袭性的非酒精性脂肪性肝炎形式,最终导致纤维化和肝硬化。NAFLD也被认为是肝外并发症的独立危险因素,如心血管疾病、2型糖尿病、睡眠障碍和骨质疏松症。在本综述中,我们讨论了儿童NAFLD的肝脏和肝外并发症。

相似文献

[1]
Nonalcoholic Fatty Liver Disease in Children: Hepatic and Extrahepatic Complications.

Pediatr Clin North Am. 2017-6

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Ferritin as an Inflammatory Marker in Pediatric Metabolic Syndrome: Links to Obesity and Liver Ultrasound Alterations.

Int J Mol Sci. 2025-4-17

[2]
Comparative analysis of gut microbiota in metabolic syndrome and obese children from Southeastern China.

Front Microbiol. 2024-12-23

[3]
Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease.

Environ Int. 2024-8

[4]
Effects of a High-Fat Diet and Docosahexaenoic Acid during Pregnancy on Fatty Acid Composition in the Fetal Livers of Mice.

Nutrients. 2023-11-6

[5]
Lifestyle interventions in nonalcoholic fatty liver disease.

Nat Rev Gastroenterol Hepatol. 2023-11

[6]
Liver Steatosis: A Marker of Metabolic Risk in Children.

Int J Mol Sci. 2022-4-27

[7]
Skeletal Muscle Mass Has Stronger Association With the Risk of Hyperuricemia Than Body Fat Mass in Obese Children and Adolescents.

Front Nutr. 2022-3-28

[8]
The adolescent with obesity: what perspectives for treatment?

Ital J Pediatr. 2022-1-15

[9]
Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease.

Front Endocrinol (Lausanne). 2021

[10]
Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes.

Front Endocrinol (Lausanne). 2021

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