Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
FEBS Lett. 2019 Oct;593(19):2706-2715. doi: 10.1002/1873-3468.13568. Epub 2019 Aug 11.
Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang-Tie signaling pathway participates in the developmental and tumor-induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang-Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end-stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang-Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.
血管生成素（Angs）是一组血管生长因子，它们具有多种与细胞存活、增殖和迁移相关的细胞功能。Angs 通过 Tie 酪氨酸激酶受体发挥生理和病理作用。Ang-Tie 信号通路参与了发育和肿瘤诱导的血管生成，并涉及许多疾病状态，如血管疾病、全身炎症和癌症。由于 Angs 在肾脏中广泛表达，因此大量研究集中在它们在肾脏中的作用上。在这篇综述中，我们描述了 Ang-Tie 信号通路的生物学功能，并总结了它们在肾脏发育和成熟、急性和慢性肾脏疾病、糖尿病肾病、狼疮性肾炎、溶血性尿毒症综合征、终末期肾脏疾病和肾细胞癌中的作用。了解 Ang-Tie 信号的分子机制可能揭示预防或缓解肾脏疾病的潜在治疗靶点。
