Scallon L J, Burke J M, Mieler W F, Kies J C, Aaberg T M
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226.
Curr Eye Res. 1988 Jul;7(7):687-93. doi: 10.3109/02713688809033198.
Canthaxanthine retinopathy in humans is a retinal crystalline deposition associated with ingestion of canthaxanthine, an over-the-counter oral tanning agent. In this study cats were fed doses of canthaxanthine varying from 2 mg/kg/day (an equivalent standard human dose) to 16 mg/kg/day for up to six months. Indirect opthalmoscopy showed progressive development of an orange sheen in the retina overlying the tapetum lucidum without evidence of crystal formation. Electroretinograms performed at one and two months showed no significant change from baseline examination. On light and transmission electron microscopic examination, the retinal pigment epithelium of the experimental animals showed an increase in cell height and a regional vacuolization due to an enlargement and disruption of some phagolysosomes and the development of cytoplasmic spaces. These observations suggest that further studies should be conducted on humans who ingest canthaxanthine to assess structural and functional alterations, especially in the pigment epithelium.
人类的斑蝥黄质视网膜病变是一种与摄入斑蝥黄质相关的视网膜晶体沉积，斑蝥黄质是一种非处方口服美黑剂。在本研究中，给猫喂食的斑蝥黄质剂量从2毫克/千克/天（相当于标准人类剂量）到16毫克/千克/天，持续长达六个月。间接检眼镜检查显示，在覆盖透明带的视网膜中逐渐出现橙色光泽，没有晶体形成的迹象。在1个月和2个月时进行的视网膜电图检查显示，与基线检查相比没有显著变化。在光镜和透射电子显微镜检查中，实验动物的视网膜色素上皮细胞高度增加，由于一些吞噬溶酶体的扩大和破坏以及细胞质间隙的形成而出现局部空泡化。这些观察结果表明，应该对摄入斑蝥黄质的人类进行进一步研究，以评估结构和功能改变，尤其是色素上皮的改变。
