Department of General Practice, School of Primary and Allied Health Care, Monash University, Melbourne, Australia.
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
J Asthma. 2020 Dec;57(12):1323-1331. doi: 10.1080/02770903.2019.1645850. Epub 2019 Aug 5.
While atopic conditions are associated with increased risk of mental health problems, the evidence that a range of allergic conditions are associated with psychological distress in young people is less clear. We recruited a longitudinal birth cohort study of 620 children with a family history of allergic disease. At the 18-year follow up, atopic sensitization was determined by skin prick testing. Surveys were used to determine psychological distress (Kessler 6), quality of life (SF12), respiratory symptoms and management, presence of current eczema and hay fever. Regression models were used to identify predictors of psychological distress and quality of life, while controlling for potential confounders. Prevalence of serious psychological distress was quite low ( = 22, 5.3%), and there were no associations between psychological distress and current atopic sensitization, symptoms of hay fever, eczema or asthma. Smoking status and lower level of maternal education were associated with lower physical quality of life (SF12 PCS subscale). Psychological distress total score, lower maternal education, smoking, female sex, and current eczema were associated with worse mental quality of life (SF12 MCS subscale). We found relatively low levels of psychological distress in this cohort of young adults, despite a high prevalence of allergic diseases. Positive social factors may serve to buffer psychological distress amongst the cohort accounting for the low prevalence of serious psychological distress observed.
虽然特应性疾病与心理健康问题的风险增加有关,但一系列过敏性疾病与年轻人心理困扰相关的证据并不明确。我们招募了一个有过敏病史的 620 名儿童的纵向出生队列研究。在 18 岁的随访中,通过皮肤点刺试验确定特应性致敏情况。使用问卷调查来确定心理困扰(Kessler 6)、生活质量(SF12)、呼吸症状和管理、当前湿疹和花粉热的存在情况。回归模型用于确定心理困扰和生活质量的预测因素,同时控制潜在的混杂因素。严重心理困扰的患病率相当低( = 22,5.3%),当前特应性致敏、花粉热、湿疹或哮喘症状与心理困扰之间没有关联。吸烟状况和较低的母亲教育水平与较低的生理生活质量(SF12 PCS 子量表)相关。心理困扰总分、较低的母亲教育水平、吸烟、女性和当前湿疹与较差的心理生活质量(SF12 MCS 子量表)相关。尽管过敏性疾病的患病率很高,但我们发现该队列中的年轻人心理困扰水平相对较低。积极的社会因素可能会减轻该队列中的心理困扰,这解释了观察到的严重心理困扰患病率较低的原因。