Akram Saeed, Nizami Imran Yaqoob, Hussein Mohamed, Saleh Waleed, Ismail Mohammed Said, AlKattan Khaled, Rajput Muhammad Shaheryar Ahmed
From the Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
From the Department of Surgery, King Faisal Specialist Hospit9al and Research Center, Riyadh, Saudi Arabia.
Ann Saudi Med. 2019 Jul-Aug;39(4):221-228. doi: 10.5144/0256-4947.2019.221. Epub 2019 Aug 5.
Lung transplantation has become a standard of care for a select group of patients with advanced lung diseases. Lung transplantation has undergone rapid growth in the last few years in Saudi Arabia.
Describe five years of experience with lung transplantation.
Retrospective, descriptive.
Major tertiary care hospital.
All patients who underwent lung transplant surgery between 2010 to 2015.
Indications for lung transplant demographics, body mass index, blood group, type of transplant surgery, morbidity rate using the Clavien-Dindo classification, rate of early- and late-onset bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans-free survival, 30- and 90-day mortality rate, and survival (30 days, 90 days, 1-year, 3-years and 5-years) for lung transplant recipients. The duration of mechanical ventilation, colonization by bacteria and need for lung volume reduction surgery for lung donors.
80, 45% women and 55% men.
The most common indication for lung transplant in Saudi Arabia is pulmonary fibrosis (45%), followed by non-cystic fibrosis bronchiectasis (25%) and cystic fibrosis-related bronchiectasis (20%). Only 45% of our lung transplant recipients had a normal BMI (18-28 kg/m). The most frequent blood group was A (40%), followed by blood group O (32.5%). Most (85%) lung transplants were bilateral while 15% were single lung transplants. Postoperative complications developed in 64 patients, 34 (42.5%) had minor grade 1 complications, while 13 (16.5%) had severe complications leading to death (grade V). Early onset BOS developed in 6 (7.5%) patients while 16 (20%) had late onset BOS. The BOS-free survival rate was 72.5%. The mean duration of mechanical ventilation in lung donors was 9 days and most were infected by bacteria. The majority of recipients required lung volume reduction. The 30-day mortality rate was 12.5% and the 90-day mortality rate was 17.5%. Survival rates at our center were 87.5% at 30 days, 82.5% at 90 days, 81.2% at 1 year, 67.9% at 2 years and 62.1% at 5 years.
Lung transplantation has become an invaluable approach for the treatment of end-stage respiratory disease. Our 5-year experience has shown exciting promises for lung transplantation in Saudi Arabia.
Retrospective design, single center experience.
None.
肺移植已成为特定晚期肺部疾病患者的治疗标准。过去几年沙特阿拉伯的肺移植数量增长迅速。
描述五年的肺移植经验。
回顾性、描述性研究。
大型三级护理医院。
2010年至2015年间接受肺移植手术的所有患者。
肺移植的适应证、人口统计学特征、体重指数、血型、移植手术类型、使用Clavien-Dindo分类法的发病率、早发性和迟发性闭塞性细支气管炎综合征（BOS）的发生率、无闭塞性细支气管炎生存率、30天和90天死亡率以及肺移植受者的生存率（30天、90天、1年、3年和5年）。肺供体的机械通气时间、细菌定植情况以及肺减容手术需求。
80例，女性占45%，男性占55%。
沙特阿拉伯肺移植最常见的适应证是肺纤维化（45%），其次是非囊性纤维化支气管扩张（25%）和囊性纤维化相关支气管扩张（20%）。我们的肺移植受者中只有45%的体重指数正常（18 - 28 kg/m²）。最常见的血型是A型（40%），其次是O型（32.5%）。大多数（85%）肺移植是双侧的，15%是单肺移植。64例患者出现术后并发症，34例（42.5%）有轻微的1级并发症，而13例（16.5%）有严重并发症导致死亡（V级）。6例（7.5%）患者出现早发性BOS，16例（20%）出现迟发性BOS。无BOS生存率为72.5%。肺供体的平均机械通气时间为9天，大多数被细菌感染。大多数受者需要进行肺减容手术。30天死亡率为12.5%，90天死亡率为17.5%。我们中心的生存率在30天时为87.5%，90天时为82.5%，1年时为81.2%，2年时为67.9%，5年时为62.1%。
肺移植已成为治疗终末期呼吸系统疾病的宝贵方法。我们的五年经验显示沙特阿拉伯的肺移植前景令人振奋。
回顾性设计，单中心经验。
无。
