Zusman S B, Sweeton D, Wieschaus E F
Princeton University, New Jersey 08544.
Dev Biol. 1988 Oct;129(2):417-27. doi: 10.1016/0012-1606(88)90389-2.
Mutations at the short gastrulation locus affect the timing of certain early morphogenetic events occurring during gastrulation in Drosophila melanogaster. Specifically, the invagination and subsequent closing of the posterior midgut and the anterior midgut appear to be delayed in these embryos. In addition, their germbands do not extent the full distance anteriorly on the dorsal side of the embryo. The dorsal cells are abnormally thick and fall into extremely deep dorsal folds as the germband extends. sog embryos continue development, but form disorganized first instar larvae. Normal sog expression is required in the zygote, but not in the mother for normal embryonic development and viability. Analysis of adult and larval gynandromorphs indicates that sog expression is required only in the ventral and/or anterior and posterior ends of the embryo, arguing that the dorsal abnormalities caused by the mutation are secondary consequences of defects elsewhere in mutant embryos.
短原肠胚形成基因座的突变会影响黑腹果蝇原肠胚形成过程中某些早期形态发生事件的时间。具体而言，这些胚胎中后肠和前肠的内陷及随后的闭合似乎会延迟。此外，它们的胚带在胚胎背侧向前延伸的距离不完全。随着胚带延伸，背侧细胞异常增厚并陷入极深的背褶中。短原肠胚形成基因（sog）突变体胚胎继续发育，但形成的一龄幼虫结构紊乱。正常胚胎发育和生存能力需要合子中正常的sog表达，但不需要母体中的正常表达。对成年和幼虫雌雄嵌合体的分析表明，sog表达仅在胚胎的腹侧和/或前端及后端是必需的，这表明由该突变导致的背侧异常是突变胚胎其他部位缺陷的继发后果。
