• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

链霉菌来源的抗真菌化合物也能抑制杜氏利什曼原虫。

Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.

机构信息

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Laboratório de Química Medicinal e Computacional, Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos-SP, Brazil.

出版信息

PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007643. doi: 10.1371/journal.pntd.0007643. eCollection 2019 Aug.

DOI:10.1371/journal.pntd.0007643
PMID:31381572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6695191/
Abstract

Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan parasite Leishmania donovani. The bioassay guided fractionation of extracts from cultures of Streptomyces sp. ICBG292, isolated from the exoskeleton of Cyphomyrmex workers, led to the isolation of Mer-A2026B (1), piericidin-A1 (2) and nigericin (3). Nigericin (3) presented high activity against intracellular amastigotes of L. donovani (IC50 0.129 ± 0.008 μM). Streptomyces puniceus ICBG378, isolated from workers of Acromyrmex rugosus rugosus, produced dinactin (4) with potent anti-L. donovani activity against intracellular amastigotes (IC50 0.018 ± 0.003 μM). Compounds 3 and 4 showed good selectivity indexes, 88.91 and 656.11 respectively, and were more active than positive control, miltefosine. Compounds 1-4 were also active against some Escovopsis strains. Compounds 1 and 2 were also produced by Streptomyces sp. ICBG233, isolated from workers of Atta sexdens, and detected in ants' extracts by mass spectrometry, suggesting they are produced in the natural environment as defensive compounds involved in the symbiotic interaction.

摘要

从 Attine 蚂蚁中分离出的细菌菌株对昆虫专性真菌病原体 Escovopsis 以及人类原生动物寄生虫利什曼原虫具有活性。从 Cyphomyrmex 工蚁外骨骼中分离出的链霉菌 ICBG292 培养物的提取物经生物测定指导分离，得到 Mer-A2026B（1）、piericidin-A1（2）和 Nigericin（3）。Nigericin（3）对 L. donovani 的细胞内无鞭毛体具有高活性（IC50 0.129 ± 0.008 μM）。从 Acromyrmex rugosus rugosus 工蚁中分离出的紫色链霉菌 ICBG378 产生了具有抗 L. donovani 活性的 dinactin（4），对细胞内无鞭毛体具有很强的活性（IC50 0.018 ± 0.003 μM）。化合物 3 和 4 具有良好的选择性指数，分别为 88.91 和 656.11，比阳性对照米替福新更有效。化合物 1-4 也对一些 Escovopsis 菌株具有活性。化合物 1 和 2 也由从 Atta sexdens 工蚁中分离出的链霉菌 ICBG233 产生，并通过质谱法在蚂蚁提取物中检测到，表明它们是作为参与共生相互作用的防御化合物在自然环境中产生的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/ed691b448ed7/pntd.0007643.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/ae07ee5c7c3e/pntd.0007643.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/d175cc1dbaba/pntd.0007643.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/ed691b448ed7/pntd.0007643.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/ae07ee5c7c3e/pntd.0007643.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/d175cc1dbaba/pntd.0007643.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e8a/6695191/ed691b448ed7/pntd.0007643.g003.jpg

相似文献

1
Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.链霉菌来源的抗真菌化合物也能抑制杜氏利什曼原虫。
PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007643. doi: 10.1371/journal.pntd.0007643. eCollection 2019 Aug.
2
A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus.单个链霉菌共生体产生多种抗真菌物质以支持真菌养殖蚁（Acromyrmex octospinosus）。
PLoS One. 2011;6(8):e22028. doi: 10.1371/journal.pone.0022028. Epub 2011 Aug 3.
3
Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311.抗利什曼原虫大环内酯类化合物来自于与蚂蚁共生的链霉菌 ISID311。
Bioorg Med Chem. 2021 Feb 15;32:116016. doi: 10.1016/j.bmc.2021.116016. Epub 2021 Jan 12.
4
Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis.产生杀假丝菌素的链霉菌帮助切叶蚁保护它们的菌圃免受病原菌埃斯科夫菌的侵害。
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4742-6. doi: 10.1073/pnas.0812082106. Epub 2009 Mar 6.
5
Actinomycetes inhibit filamentous fungi from the cuticle of Acromyrmex leafcutter ants.放线菌抑制切叶蚁角质层上的丝状真菌。
J Basic Microbiol. 2016 Mar;56(3):229-37. doi: 10.1002/jobm.201500593. Epub 2016 Jan 25.
6
Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants.成像质谱和 MS/MS 分子网络揭示了与真菌培养蚂蚁相关的表皮细菌和致病性真菌之间的化学相互作用。
Sci Rep. 2017 Jul 17;7(1):5604. doi: 10.1038/s41598-017-05515-6.
7
Broad Escovopsis-inhibition activity of Pseudonocardia associated with Trachymyrmex ants.与糙角蚁相关的假诺卡氏菌具有广泛的抑制埃斯科沃氏菌活性。
Environ Microbiol Rep. 2014 Aug;6(4):339-45. doi: 10.1111/1758-2229.12132. Epub 2014 Jan 8.
8
Chemical warfare between fungus-growing ants and their pathogens.真菌培养蚂蚁与其病原体之间的化学战。
Curr Opin Chem Biol. 2020 Dec;59:172-181. doi: 10.1016/j.cbpa.2020.08.001. Epub 2020 Sep 17.
9
Ammonia Production by Symbionts of Leaf-Cutting Ants Strongly Inhibits the Fungal Pathogen .切叶蚁共生菌产生的氨强烈抑制真菌病原体。
Microorganisms. 2021 Jul 29;9(8):1622. doi: 10.3390/microorganisms9081622.
10
Efficacy of protease inhibitor from marine Streptomyces sp. VITBVK2 against Leishmania donovani - An in vitro study.海洋链霉菌VITBVK2产生的蛋白酶抑制剂对杜氏利什曼原虫的体外研究疗效
Exp Parasitol. 2017 Mar;174:45-51. doi: 10.1016/j.exppara.2017.02.007. Epub 2017 Feb 4.

引用本文的文献

1
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks.利用放线菌次生代谢产物进行结核病药物发现：历史趋势、现状与未来展望。
Nat Prod Bioprospect. 2025 Aug 11;15(1):52. doi: 10.1007/s13659-025-00533-8.
2
Medical Potential of Insect Symbionts.昆虫共生体的医学潜力。
Insects. 2025 Apr 26;16(5):457. doi: 10.3390/insects16050457.
3
Isolation of Actinobacteria from Date Palm Rhizosphere with Enzymatic, Antimicrobial, Antioxidant, and Protein Denaturation Inhibitory Activities.

本文引用的文献

1
The antimicrobial potential of Streptomyces from insect microbiomes.昆虫微生物组中链霉菌的抗菌潜力。
Nat Commun. 2019 Jan 31;10(1):516. doi: 10.1038/s41467-019-08438-0.
2
Leishmaniasis.利什曼病。
Lancet. 2018 Sep 15;392(10151):951-970. doi: 10.1016/S0140-6736(18)31204-2. Epub 2018 Aug 17.
3
Absolute Configurations of Griseorhodins A and C.灰红菌素A和C的绝对构型
从枣椰根际分离具有酶活性、抗菌活性、抗氧化活性和蛋白质变性抑制活性的放线菌。
Biomolecules. 2025 Jan 5;15(1):65. doi: 10.3390/biom15010065.
4
Novel strains of Actinobacteria associated with neotropical social wasps (Vespidae; Polistinae, Epiponini) with antimicrobial potential for natural product discovery.与新热带地区群居黄蜂（胡蜂科；马蜂亚科，Eumenini族）相关的具有天然产物发现抗菌潜力的放线菌新菌株。
FEMS Microbes. 2024 Feb 24;5:xtae005. doi: 10.1093/femsmc/xtae005. eCollection 2024.
5
Symbiosis, dysbiosis and the impact of horizontal exchange on bacterial microbiomes in higher fungus-gardening ants.共生、失调以及水平基因交换对高等菌食性蚂蚁细菌微生物组的影响。
Sci Rep. 2024 Feb 8;14(1):3231. doi: 10.1038/s41598-024-53218-6.
6
Unravelling the potential of insects for medicinal purposes - A comprehensive review.揭示昆虫在药用方面的潜力——一篇全面综述。
Heliyon. 2023 Apr 29;9(5):e15938. doi: 10.1016/j.heliyon.2023.e15938. eCollection 2023 May.
7
Characterizing corn-straw-degrading actinomycetes and evaluating application efficiency in straw-returning experiments.表征玉米秸秆降解放线菌并评估其在秸秆还田试验中的应用效率。
Front Microbiol. 2022 Dec 5;13:1003157. doi: 10.3389/fmicb.2022.1003157. eCollection 2022.
8
Antibiotics from Insect-Associated Actinobacteria.来自与昆虫相关的放线菌的抗生素。
Biology (Basel). 2022 Nov 18;11(11):1676. doi: 10.3390/biology11111676.
9
HAS 1: A natural product from soil-isolated species with potent activity against cutaneous leishmaniasis caused by .HAS 1：一种从土壤分离物种中提取的天然产物，对由……引起的皮肤利什曼病具有强效活性。
Front Pharmacol. 2022 Oct 10;13:1023114. doi: 10.3389/fphar.2022.1023114. eCollection 2022.
10
: The biofactory of secondary metabolites.次生代谢产物的生物工厂。
Front Microbiol. 2022 Sep 29;13:968053. doi: 10.3389/fmicb.2022.968053. eCollection 2022.
Tetrahedron Lett. 2017 Dec 13;58(50):4721-4723. doi: 10.1016/j.tetlet.2017.11.008. Epub 2017 Nov 7.
4
Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway.尼格利辛通过抑制 Wnt/β-catenin 信号通路对人结肠癌细胞发挥抗癌作用。
Mol Cancer Ther. 2018 May;17(5):952-965. doi: 10.1158/1535-7163.MCT-17-0906. Epub 2018 Feb 26.
5
Streptomyces puniceus strain AS13., Production, characterization and evaluation of bioactive metabolites: A new face of dinactin as an antitumor antibiotic.紫色链霉菌 AS13. 的生产、特性及生物活性代谢产物的评估：作为一种新型抗肿瘤抗生素的二氮嗪。
Microbiol Res. 2018 Mar;207:196-202. doi: 10.1016/j.micres.2017.12.004. Epub 2017 Dec 8.
6
Evolutionary stability of antibiotic protection in a defensive symbiosis.抗生素保护在防御共生关系中的进化稳定性。
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2020-E2029. doi: 10.1073/pnas.1719797115. Epub 2018 Feb 14.
7
Calcium Ionophore, Calcimycin, Kills Promastigotes by Activating Parasite Nitric Oxide Synthase.钙离子载体A23187通过激活寄生虫一氧化氮合酶杀死前鞭毛体。
Biomed Res Int. 2017;2017:1309485. doi: 10.1155/2017/1309485. Epub 2017 Oct 18.
8
Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca Channel.米替福新对杜氏利什曼原虫作用机制涉及酸钙细胞器功能障碍和鞘氨醇依赖性质膜 Ca 通道激活。
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01614-17. Print 2018 Jan.
9
TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models.Toll样受体2（TLR2）激活可在人单核细胞-巨噬细胞系模型中诱导抗氧化防御。
Oncotarget. 2017 Apr 21;8(33):54243-54264. doi: 10.18632/oncotarget.17342. eCollection 2017 Aug 15.
10
Leishmaniasis drug discovery: recent progress and challenges in assay development.利什曼病药物发现：检测方法开发的最新进展和挑战。
Drug Discov Today. 2017 Oct;22(10):1516-1531. doi: 10.1016/j.drudis.2017.06.004. Epub 2017 Jun 21.