次生代谢产物的生物工厂。
: The biofactory of secondary metabolites.
作者信息
Alam Khorshed, Mazumder Arpita, Sikdar Suranjana, Zhao Yi-Ming, Hao Jinfang, Song Chaoyi, Wang Yanyan, Sarkar Rajib, Islam Saiful, Zhang Youming, Li Aiying
机构信息
Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Department of Microbiology, University of Chittagong, Chittagong, Bangladesh.
出版信息
Front Microbiol. 2022 Sep 29;13:968053. doi: 10.3389/fmicb.2022.968053. eCollection 2022.
Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among . It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the .
源自微生物的天然产物是有价值的药物和治疗剂的重要来源。在环境中是最普遍存在的细菌属，具有丰富的能力来产生在医学、环境、食品工业和农业领域具有显著生物活性的多样且有价值的天然产物。然而，在 中仍有许多天然产物未被探索。由于对抗生素、癌症化疗药物和杀虫剂的耐药性快速增长，开发新型抗生素、农用化学品、抗癌药物等迫在眉睫。这篇综述文章聚焦于 分泌的天然产物及其在治疗疾病和农业中的功能与重要性。此外，它还讨论了基于基因组的药物发现策略，并对来自 的药物开发给出了未来展望。
需注意，原文中部分内容缺失具体指代信息，翻译时用“ ”表示，可能会影响译文的完整性和准确性，最好能补充完整相关内容。
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