Esche B A, Haie C M, Gerbaulet A P, Eschwege F, Richard J M, Chassagne D
Institut Gustave-Roussy, Villejuif, France.
Int J Radiat Oncol Biol Phys. 1988 Sep;15(3):619-25. doi: 10.1016/0360-3016(88)90303-3.
Forty-three patients, all male, with limited epidermoid carcinoma of the soft palate and uvula were treated by interstitial implant usually associated with external radiotherapy. Most patients received 50 Gy external irradiation to the oropharynx and neck followed by 20-35 Gy by interstitial iridium-192 wires using either guide gutters or a plastic tube technique. Twelve primary tumors and two recurrences after external irradiation alone had implant only for 65-75 Gy. Total actuarial local control is 92% with no local failures in 34 T1 primary tumors. Only one serious complication was seen. Overall actuarial survival was 60% at 3 years and 37% at 5 years but cause-specific survivals were 81% and 64%. The leading cause of death was other aerodigestive cancer, with an actuarial rate of occurrence of 10% per year after treatment of a soft palate cancer. Interstitital brachytherapy alone or combined with external irradiation is safe, effective management for early carcinoma of the soft palate and uvula but second malignancy is a serious problem.
43例男性患者，均患有软腭和悬雍垂局限性表皮样癌，接受了间质植入治疗，通常联合外照射放疗。大多数患者先接受50Gy的口咽和颈部外照射，然后使用导向槽或塑料管技术通过间质铱 - 192线给予20 - 35Gy照射。12例原发肿瘤和2例单纯外照射后复发的患者仅接受了65 - 75Gy的植入治疗。34例T1期原发肿瘤无局部失败，总精算局部控制率为92%。仅观察到1例严重并发症。3年总精算生存率为60%，5年为37%，但特定病因生存率分别为81%和64%。主要死亡原因是其他气消化道癌症，软腭癌治疗后每年精算发生率为10%。间质近距离放疗单独或联合外照射是治疗软腭和悬雍垂早期癌的安全、有效方法，但第二原发恶性肿瘤是一个严重问题。
