Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics NAS Ukraine, Kyiv, Ukraine.
Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics NAS Ukraine, Kyiv, Ukraine; Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum, Karolinska Institute, Stockholm, Sweden.
Pharmacol Rep. 2019 Oct;71(5):826-832. doi: 10.1016/j.pharep.2019.04.011. Epub 2019 Apr 15.
Prostate cancer is one of the most common malignant neoplasms in men. Because of the increase in the number of cases as well as development of cancers resistant to conventional therapy, identification of the new molecular targets for the treatment and prevention is of great importance. For this purpose, many studies are aimed on revealing of molecular mechanisms of prostate cancer development. In this process, dietary lipids and environmental xenobiotics are largely involved and are considered as risk factors. A wide range of endogenous (cholesterol, polyunsaturated fatty acids, etc.) and exogenous (pollutants, drugs) compounds are metabolized in the human organism by cytochrome P450. From other hand, these compounds may alter cytochrome P450 expression levels, especially in prostate, which, in turn, affects cell metabolism. Cytochrome P450 is a member of signaling pathways, regulating cell cycle, apoptosis, invasion and adhesion. Hence, cytochrome P450 most probably plays the important role in initiation and progression of prostate cancer. Based on that, cytochrome P450 enzymes are considered as potential targets for the targeted therapy and prevention, and might serve as specific markers of malignant growth.
前列腺癌是男性最常见的恶性肿瘤之一。由于病例数量的增加以及对传统疗法产生抗药性的癌症的发展，鉴定用于治疗和预防的新的分子靶标变得非常重要。为此，许多研究旨在揭示前列腺癌发展的分子机制。在这个过程中，膳食脂质和环境污染物大量参与并被认为是危险因素。人体内的广泛的内源性（胆固醇、多不饱和脂肪酸等）和外源性（污染物、药物）化合物由细胞色素 P450 代谢。另一方面，这些化合物可能改变细胞色素 P450 的表达水平，特别是在前列腺中，这反过来又影响细胞代谢。细胞色素 P450 是调节细胞周期、细胞凋亡、侵袭和黏附的信号通路的成员。因此，细胞色素 P450 很可能在前列腺癌的发生和发展中发挥重要作用。基于这一点，细胞色素 P450 酶被认为是靶向治疗和预防的潜在靶点，并可能作为恶性生长的特异性标志物。
