Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria , Varese , Italy.
Department of Experimental Medicine, Sapienza University of Rome , Rome , Italy.
Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):697-703. doi: 10.1080/17425255.2019.1651839. Epub 2019 Aug 8.
: D-chiro-inositol (DCI) and glucose transporter inhibitors may inhibit myo-inositol (MI) transporters, and the aim is to clinically evaluate their effect on MI absorption. : Fasting 18 healthy volunteers received orally 6000 mg MI, 6000 mg MI with 1000 mg DCI, and 6000 mg MI with SelectSIEVE® Apple PCQ and Sorbitol, Maltodextrin and Sucralose (PCQ-SMS), in three different phases with a washout period of 7 days. At each phase, blood samples were collected before administration, and every 60 minutes until 540 minutes after administration. MI plasma levels (μmol/L) were quantified by gas chromatography-mass spectrometry; maximum plasma concentration (Cmax), time to reach it (Tmax), and the area under the time-concentration curve of MI (AUC 0-540) were evaluated. : The Cmax of MI alone (Tmax = 180min) was 1.29-fold higher than those of MI with DCI (Tmax = 180min) (p < 0.001) and 1.69-fold higher than those of MI with PCQ-SMS (Tmax = 240min) (p < 0.001). The AUC 0-540 was reduced by 19.09% in MI plus DCI (p = 0.0118) and by 31.8% in MI plus PCQ-SMS (p < 0.001) as compared to MI alone. : DCI, glucose transporter inhibitors and sugars, such as sorbitol and maltodextrin, seem to inhibit MI absorption, decreasing MI plasma concentration as compared to MI alone.
:D-手性肌醇（DCI）和葡萄糖转运体抑制剂可能会抑制肌醇（MI）转运体，目的是临床评估它们对 MI 吸收的影响。: 18 名健康志愿者空腹分别口服 6000mg MI、6000mg MI 加 1000mg DCI、6000mg MI 加 SelectSIEVE® Apple PCQ 和山梨醇、麦芽糊精和蔗糖（PCQ-SMS），每个阶段间隔 7 天。每个阶段给药前和给药后每 60 分钟采集一次血样，共采集 540 分钟。MI 血浆水平（μmol/L）采用气相色谱-质谱法定量；评价 MI 单独给药（Tmax=180min）、MI 加 DCI 给药（Tmax=180min）和 MI 加 PCQ-SMS 给药（Tmax=240min）时的 MI 最大血浆浓度（Cmax）、达峰时间（Tmax）和 MI 时间-浓度曲线下面积（AUC0-540）。: MI 单独给药（Tmax=180min）的 Cmax 是 MI 加 DCI 给药（Tmax=180min）的 1.29 倍（p<0.001），是 MI 加 PCQ-SMS 给药（Tmax=240min）的 1.69 倍（p<0.001）。与 MI 单独给药相比，MI 加 DCI 使 AUC0-540 减少 19.09%（p=0.0118），MI 加 PCQ-SMS 使 AUC0-540 减少 31.8%（p<0.001）。: DCI、葡萄糖转运体抑制剂和山梨醇、麦芽糊精等糖似乎会抑制 MI 的吸收，与 MI 单独给药相比，降低 MI 血浆浓度。
