Clinical Cancer Research Center, Milad General Hospital, Tehran, Iran.
Knee and Sport Medicine Research Center, Milad Hospital, Tehran, Iran.
J Ovarian Res. 2021 Oct 9;14(1):130. doi: 10.1186/s13048-021-00870-5.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in the women at their reproductive age. Nowadays, the use of herbal compounds for lesser side effects, as compared to drug treatments, has become popular for the prevention and reduction of the complications of this disease. Evidence suggests that cinnamon, given its antioxidant and anti-inflammatory properties, can be associated with reduced metabolic complications from chronic non-communicable diseases. This systematic review aimed to determine the potential effect of cinnamon on the metabolic status in the PCOS. PICO framework for current systematic review was Population (P): subjects with PCOS; Intervention (I): oral cinnamon supplement; Comparison (C): the group as control or administered placebo; and Outcome (O): changed inflammatory, oxidative stress, lipid profile, glycemic, hormonal and anthropometric parameters and ovarian function. PubMed, Scopus, EMBASE, ProQuest and Google Scholar were searched from their very inception until January, 2020, considering specific keywords to explore the related studies. Out of 266 studies retrieved by the search strategy, only nine were eligible for evaluation. All clinical trials, animal studies, and published English-language journal studies were eligible for this review. The results showed that increased high-density lipoprotein and insulin sensitivity were increased by the cinnamon supplementation while low-density lipoprotein, triglyceride, and blood glucose were decreased in patients with PCOS. However, the results related to the potential effects of cinnamon on body weight and body mass index were inconsistent, thus calling for further studies. Also, despite improved results regarding the effect of cinnamon on oxidative stress and ovarian function, further studies are required to explore the precise mechanisms. Overall, the effects of cinnamon on the improvement of metabolic status in PCOS were promising. However, to observe clinical changes following cinnamon supplementation in PCOS, more clinical trials with higher doses of cinnamon and a longer duration of intervention are needed.
多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌疾病之一。如今，与药物治疗相比，草药化合物的副作用较小，因此已被广泛用于预防和减少这种疾病的并发症。有证据表明，肉桂因其具有抗氧化和抗炎特性，可与减少慢性非传染性疾病的代谢并发症相关。本系统评价旨在确定肉桂对 PCOS 代谢状况的潜在影响。当前系统评价的 PICO 框架为：人群（P）：患有 PCOS 的受试者；干预（I）：口服肉桂补充剂；比较（C）：对照组或给予安慰剂；结局（O）：改变炎症、氧化应激、血脂谱、血糖、激素和人体测量参数以及卵巢功能。从其创立之初到 2020 年 1 月，通过搜索特定关键字，在 PubMed、Scopus、EMBASE、ProQuest 和 Google Scholar 上搜索，以探索相关研究。通过搜索策略检索到 266 项研究，只有 9 项符合评估条件。所有临床试验、动物研究和已发表的英语期刊研究均符合本综述的条件。结果表明，肉桂补充剂可增加高密度脂蛋白和胰岛素敏感性，同时降低 PCOS 患者的低密度脂蛋白、甘油三酯和血糖。然而，关于肉桂对体重和体重指数的潜在影响的结果不一致，因此需要进一步研究。此外，尽管肉桂对氧化应激和卵巢功能的影响有改善作用，但需要进一步研究以探索其确切机制。总体而言，肉桂对改善 PCOS 代谢状况的影响是有希望的。然而，为了观察 PCOS 患者在肉桂补充后的临床变化，需要进行更多具有更高剂量肉桂和更长干预时间的临床试验。
