Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, Poznań 61-712, Poland.
Gastroenterol Clin North Am. 2019 Sep;48(3):447-464. doi: 10.1016/j.gtc.2019.04.008. Epub 2019 Jun 12.
Pancreatic cancer is one of the most lethal diseases. In pancreatic cancer development and progression, genetic (gene mutations and activation of oncogenes) and environmental factors (smoking, alcohol consumption, type 2 diabetes mellitus, obesity) play an essential role. Recently, molecular studies revealed that dysbiosis of microbiota also has influence on cancer development. Research indicates that bacteria and viruses can lead to chronic inflammation, antiapoptotic changes, cell survival, and cell invasion. This review presents bacteria and viruses oncogenic for the pancreas. Possible mechanisms of carcinogenic action are also described.
胰腺癌是最致命的疾病之一。在胰腺癌的发生和发展过程中，遗传因素（基因突变和癌基因的激活）和环境因素（吸烟、饮酒、2 型糖尿病、肥胖）起着重要作用。最近，分子研究表明，微生物群落失调也会影响癌症的发展。研究表明，细菌和病毒可导致慢性炎症、抗细胞凋亡改变、细胞存活和细胞侵袭。本综述介绍了胰腺致癌的细菌和病毒。还描述了致癌作用的可能机制。
