Center of Biotherapy, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Gut Microbes. 2022 Jan-Dec;14(1):2073785. doi: 10.1080/19490976.2022.2073785.
Intratumor microbiome shapes the immune system and influences the outcome of various tumors. (), the keystone periodontal pathogen, is highly epidemically connected with pancreatic cancer (PC). However, its causative role and the underlining mechanism in promoting PC oncogenesis remain unclear. Here, we illustrated the landscape of intratumor microbiome and its bacterial correlation with oral cavity in PC patients, where presented both in the oral cavity and tumor tissues. When exposed to , tumor development was accelerated in orthotopic and subcutaneous PC mouse model, and the cancerous pancreas exhibited a neutrophils-dominated proinflammatory tumor microenvironment. Mechanistically, the intratumoral promoted PC progression via elevating the secretion of neutrophilic chemokines and neutrophil elastase (NE). Collectively, our study disclosed the bacterial link between periodontitis and PC, and revealed a previously unrecognized mechanism of in PC pathophysiology, hinting at therapeutic implications.
肿瘤内微生物组塑造免疫系统并影响各种肿瘤的预后。（），一种主要的牙周病原体，与胰腺癌（PC）高度流行相关。然而，其在促进 PC 致癌中的因果作用及其潜在机制仍不清楚。在这里，我们描绘了 PC 患者肿瘤内微生物组及其与口腔的细菌相关性，其中（）同时存在于口腔和肿瘤组织中。当暴露于（）时，原位和皮下 PC 小鼠模型中的肿瘤发展加速，癌变胰腺表现出以中性粒细胞为主的促炎肿瘤微环境。从机制上讲，肿瘤内（）通过提高中性粒细胞趋化因子和中性粒细胞弹性蛋白酶（NE）的分泌来促进 PC 的进展。总之，我们的研究揭示了牙周炎和 PC 之间的细菌联系，并揭示了（）在 PC 病理生理学中的一个以前未被认识的机制，提示了治疗意义。
