Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Vet Microbiol. 2019 Aug;235:243-247. doi: 10.1016/j.vetmic.2019.07.010. Epub 2019 Jul 10.
The combination of a macrolide and rifampicin has been the mainstay of therapy in foals with Rhodococcus equi pneumonia for decades. Recent studies suggest that mass antimicrobial treatment of subclinically affected foals over time has selected for antimicrobial resistance. Our objective was to estimate the prevalence of R. equi strains resistant to macrolides and rifampicin at horse breeding farms in Kentucky. A hundred breeding farms in Kentucky were surveyed and R. equi were cultured from soil samples. Data were analyzed with logistic regression and generalized linear modeling (P < 0.05). Seventy-six percent (76%) of farms yielded resistant R. equi, and resistance to macrolides and rifampicin was associated with their use at farms. The present study is the first to report the prevalence and distribution of resistant isolates in the environment of farms in Kentucky, USA. Collectively, previous reports and the data presented herein provide irrefutable evidence of emerging antimicrobial resistance in R. equi with alarming prevalence. Widespread dissemination and maintenance of resistance genes in the environment where many other pathogenic bacteria exist is a concern for both animal and human health.
几十年来，大环内酯类药物和利福平的联合应用一直是马传染性胸膜肺炎驹治疗的主要方法。最近的研究表明，随着时间的推移，对亚临床感染驹进行大规模的抗菌治疗选择了具有抗药性的微生物。我们的目的是估计肯塔基州种马场中耐大环内酯类药物和利福平的马传染性贫血菌菌株的流行率。对肯塔基州的 100 个种马场进行了调查，并从土壤样本中培养了马传染性贫血菌。采用逻辑回归和广义线性模型进行数据分析（P<0.05）。76%的农场产生了耐药的马传染性贫血菌，并且对大环内酯类药物和利福平的耐药性与它们在农场的使用有关。本研究首次报告了美国肯塔基州种马场环境中耐药分离株的流行率和分布。综上所述，以前的报告和本文提供的数据无可辩驳地证明了马传染性贫血菌中出现了令人震惊的流行率的抗微生物药物耐药性。在存在许多其他病原菌的环境中，耐药基因的广泛传播和维持是动物和人类健康的一个关注问题。
