发育迟缓的产前和产后决定因素的相对重要性:孟加拉国 MINIMat 队列的数据分析方法。

Relative importance of prenatal and postnatal determinants of stunting: data mining approaches to the MINIMat cohort, Bangladesh.

机构信息

Women's and Children's Health, Uppsala Universitet, Uppsala, Sweden

Center for Epidemiology and Community Medicine, Stockholm, Sweden.

出版信息

BMJ Open. 2019 Aug 5;9(8):e025154. doi: 10.1136/bmjopen-2018-025154.

Abstract

INTRODUCTION

WHO has set a goal to reduce the prevalence of stunted child growth by 40% by the year 2025. To reach this goal, it is imperative to establish the relative importance of risk factors for stunting to deliver appropriate interventions. Currently, most interventions take place in late infancy and early childhood. This study aimed to identify the most critical prenatal and postnatal determinants of linear growth 0-24 months and the risk factors for stunting at 2 years, and to identify subgroups with different growth trajectories and levels of stunting at 2 years.

METHODS

Conditional inference tree-based methods were applied to the extensive Maternal and Infant Nutrition Interventions in Matlab trial database with 309 variables of 2723 children, their parents and living conditions, including socioeconomic, nutritional and other biological characteristics of the parents; maternal exposure to violence; household food security; breast and complementary feeding; and measurements of morbidity of the mothers during pregnancy and repeatedly of their children up to 24 months of age. Child anthropometry was measured monthly from birth to 12 months, thereafter quarterly to 24 months.

RESULTS

Birth length and weight were the most critical factors for linear growth 0-24 months and stunting at 2 years, followed by maternal anthropometry and parental education. Conditions after birth, such as feeding practices and morbidity, were less strongly associated with linear growth trajectories and stunting at 2 years.

CONCLUSION

The results of this study emphasise the benefit of interventions before conception and during pregnancy to reach a substantial reduction in stunting.

摘要

简介

世界卫生组织(WHO)设定了一个目标,即在 2025 年之前将发育迟缓儿童的患病率降低 40%。为了实现这一目标,必须确定发育迟缓的风险因素的相对重要性,以便提供适当的干预措施。目前,大多数干预措施都发生在婴儿后期和幼儿期。本研究旨在确定 0-24 个月线性生长的最关键产前和产后决定因素,以及 2 岁时发育迟缓的风险因素,并确定具有不同生长轨迹和 2 岁时不同发育迟缓水平的亚组。

方法

采用条件推理树方法对 2723 名儿童、其父母和生活条件的广泛母婴营养干预试验数据库进行分析,共包括 309 个变量,包括父母的社会经济、营养和其他生物学特征;母亲遭受暴力的情况;家庭粮食安全;母乳喂养和补充喂养;以及母亲在怀孕期间和孩子 24 个月内的健康状况测量。儿童的人体测量学从出生到 12 个月每月测量一次,之后每季度测量一次到 24 个月。

结果

出生长度和体重是 0-24 个月线性生长和 2 岁时发育迟缓的最关键因素,其次是母亲的人体测量学和父母的教育程度。出生后条件,如喂养方式和发病率,与线性生长轨迹和 2 岁时的发育迟缓的关联较弱。

结论

本研究结果强调了在受孕前和怀孕期间进行干预的益处,以大幅减少发育迟缓。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72ca/6687011/f61544de4c18/bmjopen-2018-025154f01.jpg

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