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印度儿童慢性营养不良的风险因素:评估相对重要性、人群归因风险及比例。

Risk factors for chronic undernutrition among children in India: Estimating relative importance, population attributable risk and fractions.

作者信息

Corsi Daniel J, Mejía-Guevara Iván, Subramanian S V

机构信息

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Harvard Center for Population & Development Studies, Cambridge, MA, USA.

出版信息

Soc Sci Med. 2016 May;157:165-85. doi: 10.1016/j.socscimed.2015.11.014. Epub 2015 Nov 14.

Abstract

Nearly 40% of the world's stunted children live in India and the prevalence of undernutrition has been persistently high in recent decades. Given numerous available interventions for reducing undernutrition in children, it is not clear of the relative importance of each within a multifactorial framework. We assess the simultaneous contribution of 15 known risk factors for child chronic undernutrition in India. Data are from the 3rd Indian National Family Health Survey (NFHS-3), a nationally representative cross-sectional survey undertaken in 2005-2006. The study population consisted of children aged 6-59 months [n = 26,842 (stunting/low height-for-age), n = 27,483 (underweight/low weight-for-age)]. Risk factors examined for their association with undernutrition were: vitamin A supplementation, vaccination, use of iodized salt, household air quality, improved sanitary facilities, safe disposal of stools, improved drinking water, prevalence of infectious disease, initiation of breastfeeding, dietary diversity, age at marriage, maternal BMI, height, education, and household wealth. Age/sex-adjusted and multivariable adjusted effect sizes (odds ratios) were calculated for risk factors along with Population Attributable Risks (PAR) and Fractions (PAF) using logistic regression. In the mutually adjusted models, the five most important predictors of childhood stunting/underweight were short maternal stature, mother having no education, households in lowest wealth quintile, poor dietary diversity, and maternal underweight. These five factors had a combined PAR of 67.2% (95% CI: 63.3-70.7) and 69.7% (95% CI: 66.3-72.8) for stunting and underweight, respectively. The remaining factors were associated with a combined PAR of 11.7% (95% CI: 6.0-17.4) and 15.1% (95% CI: 8.9-21.3) for stunting and underweight, respectively. Implementing strategies focused on broader progress on social circumstances and infrastructural domains as well as investments in nutrition specific programs to promote dietary adequacy and diversity are required to ensure a long term trajectory of optimal child growth and development in India.

摘要

全球近40%发育迟缓的儿童生活在印度,近几十年来,营养不良的患病率一直居高不下。鉴于有多种可用于减少儿童营养不良的干预措施,在多因素框架内,尚不清楚每种措施的相对重要性。我们评估了印度儿童慢性营养不良的15种已知风险因素的综合作用。数据来自2005 - 2006年开展的第三次印度全国家庭健康调查(NFHS - 3),这是一项具有全国代表性的横断面调查。研究人群包括6至59个月大的儿童[发育迟缓/年龄别身高低的儿童n = 26,842,体重不足/年龄别体重低的儿童n = 27,483]。研究了与营养不良相关的风险因素:维生素A补充、疫苗接种、碘盐使用、家庭空气质量、卫生设施改善、粪便安全处理、饮用水改善、传染病患病率、母乳喂养开始情况、饮食多样性、结婚年龄、母亲体重指数、身高、教育程度和家庭财富。使用逻辑回归计算了风险因素的年龄/性别调整和多变量调整效应大小(比值比)以及人群归因风险(PAR)和人群归因分数(PAF)。在相互调整的模型中,儿童发育迟缓/体重不足的五个最重要预测因素是母亲身材矮小、母亲未受过教育、家庭处于最贫困财富五分位数、饮食多样性差和母亲体重不足。这五个因素对发育迟缓和体重不足的综合PAR分别为67.2%(95%CI:63.3 - 70.7)和69.7%(95%CI:66.3 - 72.8)。其余因素对发育迟缓和体重不足的综合PAR分别为11.7%(95%CI:6.0 - 17.4)和15.1%(95%CI:8.9 - 21.3)。为确保印度儿童实现最佳生长发育的长期轨迹,需要实施侧重于社会环境和基础设施领域更广泛进展的战略,以及对促进饮食充足和多样性的营养特定项目进行投资。

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