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儿童乳糜泻:在资源有限环境中提高认知的必要性。

Coeliac disease in children: the need to improve awareness in resource-limited settings.

作者信息

Paul Siba Prosad, Stanton Lauren Katie, Adams Helen Louise, Basude Dharamveer

机构信息

General Paediatrics, Torbay Hospital, Torquay, UK.

Peninsula Medical School, University of Plymouth, Plymouth, UK.

出版信息

Sudan J Paediatr. 2019;19(1):6-13. doi: 10.24911/SJP.106-1549488256.

Abstract

Coeliac disease (CD) is an immune-mediated systemic disorder caused by the ingestion of gluten. In children, it may present with intestinal or extra-intestinal manifestations such as diarrhoea, weight loss, iron deficiency anaemia or faltering growth. Diagnosis is confirmed by small bowel biopsies showing histological changes consistent with enteropathy. In 2012, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition revised the CD guidelines and suggested that, in a selective group of symptomatic children, CD can be diagnosed without the need for small-bowel biopsies. Management of CD is through strict adherence to a life-long gluten-free diet (GFD). CD is of great public health significance as its prevalence in developing countries has been found to be similar to that in developed countries. Early recognition and treatment improves prognosis. Patients and families require long term support to enable effective adherence to a GFD lifestyle. This alone can be challenging, but through support of health professionals and dietitians, can improve patient outcomes. In resource-limited settings medical professionals need to be creative in formulating cheaper and locally sourced gluten free options in close cooperation with the dietitians thereby ensuring availability of gluten free food items at affordable prices. In this paper, we gave an overview of the subject followed by authors' view to emphasize the need for improved awareness in resource-limited settings.

摘要

乳糜泻(CD)是一种由摄入麸质引发的免疫介导性全身性疾病。在儿童中,它可能表现为肠道或肠道外症状,如腹泻、体重减轻、缺铁性贫血或生长发育迟缓。通过小肠活检显示与肠病相符的组织学变化来确诊。2012年,欧洲儿科胃肠病学、肝病学和营养学会修订了CD指南,并建议,在一组有症状的特定儿童中,无需进行小肠活检即可诊断CD。CD的治疗方法是严格坚持终身无麸质饮食(GFD)。CD具有重大的公共卫生意义,因为在发展中国家已发现其患病率与发达国家相似。早期识别和治疗可改善预后。患者及其家庭需要长期支持,以有效坚持GFD生活方式。仅这一点就可能具有挑战性,但通过健康专业人员和营养师的支持,可以改善患者的治疗效果。在资源有限的环境中,医学专业人员需要发挥创造力,与营养师密切合作,制定更便宜且本地可得的无麸质选择,从而确保以可承受的价格提供无麸质食品。在本文中,我们对该主题进行了概述,随后阐述了作者的观点,以强调在资源有限的环境中提高认识的必要性。

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