Dubray Quentin, Diallo Taibou, Loeuillet Richard, Andre Emilie, Fauqueur Anne-Sophie, Poil Sandrine, Thromas Nathalie, Secretan Philippe-Henri, Cisternino Salvatore, Schlatter Joël
Pharmacie, Hôpital Universitaire Necker - Enfants Malades, Paris, France.
Faculté de pharmacie de Paris, Université Paris Descartes, Paris, France.
SAGE Open Med. 2019 Jul 27;7:2050312119866970. doi: 10.1177/2050312119866970. eCollection 2019.
The global professional risk assessment applied to the central unit of antineoplastic agent preparations is part of a mandatory approach required by the European legislation for workers. This study identified the hazardous situations related to the staff activity and then enabled the preparation of a formal plan of occupational prevention.
The nature of study approved by a working group constituted by experts was the global risk analysis. After identifying the hazardous situations, the global risk analysis estimated the risk level of each hazardous situation based on a criticality score, including severity and frequency. The global risk analysis highlighted the initial and residual risks after establishing a plan to reduce the high criticality risks.
Hence, 33 unacceptable hazardous situations were identified. The critical categories of professional risks were "Product, emissions, and waste risks" with 17 (55%) hazardous situations; "Psychosocial risk factors" with 8 (24%) hazardous situations; and "Risks related to work equipment" with 6 (18%) hazardous situations. Once the risk reduction plan was in place, all hazardous situations were considered under control. The corrective actions led to a reorganization of human resources, the update of protection protocols, and optimization of ergonomic work tools. Staff-specific medical monitoring and regular surface contamination tests have been scheduled annually. In addition, initial and continuous training, specific to product and waste risks, has been updated.
The global professional risk assessment related to centralized antineoplastic agent preparation unit generated failure in our system and enabled corrective actions for staff safety.
应用于抗肿瘤药物制剂中心单元的全球职业风险评估是欧洲立法要求对工作人员采取的强制性措施的一部分。本研究确定了与工作人员活动相关的危险情况，进而制定了正式的职业预防计划。
由专家组成的工作组批准的研究性质为全球风险分析。在确定危险情况后，全球风险分析根据包括严重性和频率在内的关键度评分来估计每种危险情况的风险水平。全球风险分析在制定降低高关键度风险的计划后，突出了初始风险和残余风险。
因此，确定了33种不可接受的危险情况。职业风险的关键类别为“产品、排放和废物风险”，有17种（55%）危险情况；“社会心理风险因素”，有8种（24%）危险情况；以及“与工作设备相关的风险”，有6种（18%）危险情况。一旦风险降低计划实施，所有危险情况都被视为得到控制。纠正措施导致了人力资源的重组、防护协议的更新以及人体工程学工作工具的优化。已安排每年进行针对工作人员的医学监测和定期表面污染测试。此外，针对产品和废物风险的初始培训和持续培训也已更新。
与集中式抗肿瘤药物制剂单元相关联的全球职业风险评估在我们的系统中发现了问题，并促成了针对工作人员安全的纠正措施。
