Sharifian Mohammad Reza, Mahmoudi Mahmoud, Pourmomenarabi Babak, Keramati Mohammad Reza
Department of Otorhinolaryngology-Head & Neck Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Otorhinolaryngol. 2019 Jul;31(105):209-215.
Otitis media with effusion (OME) is prevalent among children in such a way that it is the most common cause of hearing loss and surgery in childhood. Immunoglobulin E (IgE) mediated hypersensitivity has been proposed as a causative factor in the development of OME; however, there has been contrasting data in this regard. Therefore, the present study aimed to detect the possibilities of interconnection.
In this study, 37 OME children were selected as the case group and 52 children were randomly chosen as the control group. Allergic rhinitis prevalence, serum total IgE concentration, serum eosinophil count, and nasal scraping cytology were evaluated in all the children. Furthermore, the skin prick test was performed in the OME group and suspected allergic rhinitis patients in the control group.
Allergic rhinitis prevalence was notably higher among OME patients than in the control group (P0.01). There were no remarkable differences in eosinophil counts and serum IgE concentrations in the two groups. Nasal smear eosinophils did not show any significant difference between the two groups; however, Appreciable difference was observed in the allergic rhinitis patients, compared to other OME patients (P0.004).
There may be a correlation between allergic rhinitis and development of OME. Therefore, it seems reasonable to examine allergic rhinitis patients for OME.
分泌性中耳炎（OME）在儿童中很常见，是儿童听力丧失和手术的最常见原因。免疫球蛋白E（IgE）介导的超敏反应被认为是OME发病的一个致病因素；然而，这方面的数据存在矛盾。因此，本研究旨在检测两者之间相互关联的可能性。
在本研究中，选取37例OME患儿作为病例组，随机选取52例儿童作为对照组。对所有儿童评估变应性鼻炎患病率、血清总IgE浓度、血清嗜酸性粒细胞计数和鼻拭子细胞学检查。此外，对OME组和对照组中疑似变应性鼻炎的患者进行皮肤点刺试验。
OME患者的变应性鼻炎患病率显著高于对照组（P<0.01）。两组的嗜酸性粒细胞计数和血清IgE浓度无显著差异。两组鼻涂片嗜酸性粒细胞无显著差异；然而，与其他OME患者相比，变应性鼻炎患者有明显差异（P<0.004）。
变应性鼻炎与OME的发生之间可能存在关联。因此，对变应性鼻炎患者进行OME检查似乎是合理的。
