Caffarelli C, Savini E, Giordano S, Gianlupi G, Cavagni G
Paediatric Department, University of Parma, Italy.
Clin Exp Allergy. 1998 May;28(5):591-6. doi: 10.1046/j.1365-2222.1998.00284.x.
Contrasting data have been found on the prevalence of atopy in children with otitis media with effusion (OME). A major issue would be to determine whether screening for atopy should be recommended. Setting Centre for Study of Otitis Media with Effusion, Tabiano Terme, Parma, Italy.
The purpose of this study was to investigate the relation of OME to atopy.
The subjects were 172 children with OME and a control group of 200 children. The protocol included a questionnaire survey of diseases associated with atopy, a skin-prick test and a clinical evaluation of allergic symptoms and hypersensitivity to aeroallergens.
No significant difference between patients and control group was observed for family history of atopy or positive skin-prick test reactions. Symptoms associated with atopy occurred significantly more frequently in the group with OME (P<0.001), though only the presence of rhinitis or atopic eczema was significantly associated with OME.
Prevalence of positive skin-prick tests results is not enhanced in children with OME. Nevertheless, the association of OME with symptoms associated with atopy suggests that such concomitant diseases may play a part in the pathogenesis of the disorder. Children with allergic rhinitis or atopic eczema should be investigated by tympanometry for OME.
关于分泌性中耳炎（OME）患儿特应性疾病的患病率，已发现相互矛盾的数据。一个主要问题是确定是否应建议进行特应性疾病筛查。研究地点为意大利帕尔马塔比亚诺泰尔梅的分泌性中耳炎研究中心。
本研究旨在探讨分泌性中耳炎与特应性疾病之间的关系。
研究对象为172例分泌性中耳炎患儿和200例儿童对照组。研究方案包括对与特应性疾病相关的疾病进行问卷调查、皮肤点刺试验以及对过敏症状和对空气过敏原的超敏反应进行临床评估。
在特应性疾病家族史或皮肤点刺试验阳性反应方面，患者组与对照组之间未观察到显著差异。与特应性疾病相关的症状在分泌性中耳炎组中出现的频率明显更高（P<0.001），不过只有鼻炎或特应性皮炎的存在与分泌性中耳炎显著相关。
分泌性中耳炎患儿皮肤点刺试验阳性结果的患病率并未增加。然而，分泌性中耳炎与特应性疾病相关症状之间的关联表明，这些伴随疾病可能在该疾病的发病机制中起作用。患有过敏性鼻炎或特应性皮炎的儿童应通过鼓室图检查来排查分泌性中耳炎。
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