Jafarirad Sima, Mansoori Anahita, Adineh Ahmad, Panahi Yunes, Hadi Amir, Goodarzi Reza
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.
Nutrition Department, Paramedical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.
Clin Nutr Res. 2019 Jul 11;8(3):196-208. doi: 10.7762/cnr.2019.8.3.196. eCollection 2019 Jul.
Curcumin is the principal polylphenol of turmeric that has been used to treat various disorders. However, its anti-obesity effects in patients with non-alcoholic fatty liver disease (NAFLD) remain controversial. Therefore, we aimed to perform a meta-analysis on the effects of supplementation with turmeric/curcumin on body weight, body mass index (BMI) and waist circumference (WC) in these patients. PubMed, Scopus, Cochrane Library, and ISI Web of Science were searched until January 2019, without any restrictions. Clinical trials that reported body weight, BMI and WC in patients with NAFLD were included. Weighted mean differences (WMDs) were pooled using a random-effects model. Eight studies (449 participants) fulfilled the eligibility criteria of the present meta-analysis. Overall, meta-analysis could not show any beneficial effect of turmeric/curcumin supplementation on body weight (WMD, -0.54 kg; 95% confidence interval [CI], -2.40, 1.31; p = 0.56; = 0.0%), BMI (WMD, -0.21 kg/m; 95% CI, -0.71, 0.28; p = 0.39; = 0.0%) and WC (WMD, -0.88 cm; 95% CI, -3.76, 2.00; p = 0.54; = 0.0%). Subgroup analysis based on participants' baseline BMI, type of intervention, and study duration did not show any significant association in all subgroups. The results showed that turmeric/curcumin supplementation had no significant effect on body weight, BMI and WC in patients with NAFLD. Further studies with large-scale are needed to find out possible anti-obesity effects of turmeric/curcumin.
姜黄素是姜黄的主要多酚类物质，已被用于治疗多种疾病。然而，其对非酒精性脂肪性肝病（NAFLD）患者的抗肥胖作用仍存在争议。因此，我们旨在对补充姜黄/姜黄素对这些患者体重、体重指数（BMI）和腰围（WC）的影响进行荟萃分析。检索了截至2019年1月的PubMed、Scopus、Cochrane图书馆和ISI科学网，没有任何限制。纳入了报告NAFLD患者体重、BMI和WC的临床试验。使用随机效应模型汇总加权平均差异（WMD）。八项研究（449名参与者）符合本荟萃分析的纳入标准。总体而言，荟萃分析未显示补充姜黄/姜黄素对体重（WMD，-0.54 kg；95%置信区间[CI]，-2.40，1.31；p = 0.56；I² = 0.0%）、BMI（WMD，-0.21 kg/m²；95%CI，-0.71，0.28；p = 0.39；I² = 0.0%）和WC（WMD，-0.88 cm；95%CI，-3.76，2.00；p = 0.54；I² = 0.0%）有任何有益影响。基于参与者基线BMI、干预类型和研究持续时间的亚组分析在所有亚组中均未显示任何显著关联。结果表明，补充姜黄/姜黄素对NAFLD患者的体重、BMI和WC没有显著影响。需要进一步进行大规模研究以发现姜黄/姜黄素可能的抗肥胖作用。
