Division of Clinical Nutrition, Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.
Department of Pharmacy, Khon Kaen Hospital, Khon Kaen, Thailand.
Am J Clin Nutr. 2023 May;117(5):1005-1016. doi: 10.1016/j.ajcnut.2023.03.006. Epub 2023 Mar 9.
Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its antioxidative and anti-inflammatory properties.
An umbrella review and updated meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effect of curcumin supplementation on anthropometric indices.
Systematic reviews and meta-analyses (SRMAs) of RCTs were identified from electronic databases (Medline, Scopus, Cochrane, and Google Scholar) up to 31 March, 2022, without language restriction. SRMAs were included if they assessed curcumin supplementation on any of the following: BMI, body weight (BW), or waist circumference (WC). Subgroup analyses were performed, stratifying by patient types, severity of obesity, and curcumin formula. The study protocol was a priori registered.
From an umbrella review, 14 SRMAs with 39 individual RCTs were included with a high degree of overlap. In addition, searching was updated from the last search of included SRMAs in April 2021 up to 31 March, 2022, and we found 11 additional RCTs, bringing the total up to 50 RCTs included in the updated meta-analyses. Of these, 21 RCTs were deemed of high risk of bias. Curcumin supplementation significantly reduced BMI, BW, and WC with mean differences (MDs) of -0.24 kg/m (95% CI: -0.32, -0.16 kg/m), -0.59 kg (95% CI: -0.81, -0.36 kg), and -1.32 cm (95% CI: -1.95, -0.69 cm), respectively. The bioavailability-enhanced form reduced BMI, BWs, and WC more, with MDs of -0.26 kg/m (95% CI: -0.38, -0.13 kg/m), -0.80 kg (95% CI: -1.38, -0.23 kg) and -1.41 cm (95% CI: -2.24, -0.58 cm), respectively. Significant effects were also seen in subgroups of patients, especially in adults with obesity and diabetes.
Curcumin supplementation significantly reduces anthropometric indices, and bioavailability-enhanced formulas are preferred. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction. This trial was registered at PROSPERO as CRD42022321112 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022321112).
姜黄素补充剂通过其抗氧化和抗炎特性，可能有助于减轻体重和改善肥胖相关并发症。
进行系统综述和荟萃分析，以评估姜黄素补充剂对人体测量指标的影响。
检索电子数据库（Medline、Scopus、Cochrane 和 Google Scholar）中截至 2022 年 3 月 31 日的随机对照试验（RCT）的系统综述和荟萃分析，无语言限制。如果系统综述评估了姜黄素补充剂对以下任何一项的影响，则将其纳入：BMI、体重（BW）或腰围（WC）。进行了亚组分析，按患者类型、肥胖严重程度和姜黄素配方进行分层。该研究方案已预先注册。
从伞式综述中，纳入了 14 项系统综述和 39 项单独的 RCT，这些研究之间存在高度重叠。此外，从 2021 年 4 月纳入的系统综述的最后一次检索中进行了更新，直到 2022 年 3 月 31 日，我们发现了另外 11 项 RCT，使更新后的荟萃分析总共纳入了 50 项 RCT。其中，21 项 RCT 被认为存在较高的偏倚风险。姜黄素补充剂可显著降低 BMI、BW 和 WC，平均差值（MD）分别为-0.24kg/m（95%CI：-0.32，-0.16kg/m）、-0.59kg（95%CI：-0.81，-0.36kg）和-1.32cm（95%CI：-1.95，-0.69cm）。生物利用度增强的形式降低 BMI、BW 和 WC 的效果更明显，MD 分别为-0.26kg/m（95%CI：-0.38，-0.13kg/m）、-0.80kg（95%CI：-1.38，-0.23kg）和-1.41cm（95%CI：-2.24，-0.58cm）。在患者亚组中也观察到了显著的效果，尤其是肥胖和糖尿病患者。
姜黄素补充剂可显著降低人体测量指标，生物利用度增强的配方更为有效。将生活方式改变与姜黄素补充剂联合使用可能是减轻体重的一种选择。该试验在 PROSPERO 注册为 CRD42022321112（https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022321112）。
