蔓越莓对心血管代谢危险因素的影响：系统评价和荟萃分析。

The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis.

机构信息

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Halal Research Center of IRI, FDA, Tehran, Iran; Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Clin Nutr. 2020 Mar;39(3):774-788. doi: 10.1016/j.clnu.2019.04.003. Epub 2019 Apr 11.

DOI:10.1016/j.clnu.2019.04.003

PMID:31023488

Abstract

BACKGROUND & AIMS: The impetus for the current study was to evaluate the efficacy of cranberry supplementation on cardiovascular disease metabolic risk factors in adult populations.

METHODS

A systematic review was conducted on PubMed, Scopus, Web of Science and Google Scholar up to June 2018, to identify randomized controlled trials investigating the effect of cranberry supplementation on cardiovascular metabolic risk factors.

RESULTS

The results of the pooled effect size indicated that cranberry administration significantly reduced systolic blood pressure and body mass index. No statistically significant change was observed in triacylglycerol, total cholesterol, low-density lipoprotein, high-density lipoprotein, fasting plasma glucose, fasting insulin, homeostasis model assessment of insulin resistance, diastolic blood pressure, waist circumference, C-reactive protein, and intercellular adhesion molecule. Stratified analysis showed that SBP reduction was more pronounced in studies with ≥50 mean age participants. Also, subgroup analysis suggested a significant increase in high-density lipoprotein concentrations in subgroups with subjects <50 mean age, and triacylglycerol levels in subsets with cranberry administered in juice form.

CONCLUSIONS

This systematic review and meta-analysis suggests cranberry supplementation may be effective in managing systolic blood pressure, body mass index and high-density lipoprotein in younger adults. Further high-quality studies are needed to confirm these results.

摘要

背景与目的

本研究旨在评估蔓越莓补充剂对成年人群心血管疾病代谢危险因素的疗效。

方法

对 PubMed、Scopus、Web of Science 和 Google Scholar 进行了系统评价，检索时间截至 2018 年 6 月，以确定评估蔓越莓补充剂对心血管代谢危险因素影响的随机对照试验。

结果

汇总效应量的结果表明，蔓越莓的使用可显著降低收缩压和体重指数。三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、空腹血糖、空腹胰岛素、胰岛素抵抗的稳态模型评估、舒张压、腰围、C 反应蛋白和细胞间黏附分子均无统计学意义上的变化。分层分析表明，在平均年龄≥50 岁的研究中，收缩压降低更为明显。此外，亚组分析表明，在年龄<50 岁的亚组中，高密度脂蛋白浓度显著升高，在以果汁形式给予蔓越莓的亚组中，三酰甘油水平升高。