Arab Arman, Hadi Amir, Moosavian Seyedeh Parisa, Rafie Nahid, Hajianfar Hossein
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Halal Research Center of IRI, FDA, Tehran 314715311, Iran.
Clin Nutr Res. 2019 Jul 29;8(3):238-246. doi: 10.7762/cnr.2019.8.3.238. eCollection 2019 Jul.
The aim of this study was to assess the effects of a nutrition education program on overweight/obese patients with non-alcoholic fatty liver disease (NAFLD). This single-blind, parallel randomized controlled trial was conducted on 82 NAFLD patients (mean age 48.89 ± 9.85 years) in Isfahan, Iran. Patients were randomly allocated to receive nutrition education program combined with usual care or usual care alone for 2 months. Metabolic markers, including lipid profile, fasting blood glucose (FBG) and dietary intakes were obtained for each patient at baseline and at the end of the study. Nutrition education intervention resulted in a significant decrease compared with usual care in serum levels of total cholesterol (TC) and triglyceride (TG) (p < 0.05). However, our intervention did not lead to a significant improvement in FBG, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), respectively (p > 0.05). Furthermore, energy and sugar intakes of patients were reduced significantly in response to our intervention (p < 0.05). Nutrition education intervention significantly reduced serum levels of TC and TG but did not affect other metabolic markers including FBG, LDL-C, and HDL-C. Also, it could reduce total energy and sugar intake. Thus, this study could be useful to use this educational program for NAFLD patients in order to influence their metabolic markers and dietary intakes.
IRCT Identifier: IRCT2014101811763N17.
本研究的目的是评估营养教育计划对超重/肥胖非酒精性脂肪性肝病（NAFLD）患者的影响。这项单盲、平行随机对照试验在伊朗伊斯法罕的82名NAFLD患者（平均年龄48.89±9.85岁）中进行。患者被随机分配接受营养教育计划联合常规护理或仅接受常规护理，为期2个月。在基线和研究结束时，为每位患者获取代谢指标，包括血脂谱、空腹血糖（FBG）和饮食摄入量。与常规护理相比，营养教育干预使血清总胆固醇（TC）和甘油三酯（TG）水平显著降低（p<0.05）。然而，我们的干预分别未导致FBG、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）有显著改善（p>0.05）。此外，患者的能量和糖摄入量因我们的干预而显著减少（p<0.05）。营养教育干预显著降低了血清TC和TG水平，但未影响包括FBG、LDL-C和HDL-C在内的其他代谢指标。此外，它可以减少总能量和糖摄入量。因此，本研究对于将该教育计划用于NAFLD患者以影响其代谢指标和饮食摄入量可能是有用的。
IRCT标识符：IRCT2014101811763N17。
