Arab Arman, Askari Gholamreza, Golshiri Parastoo, Feizi Awat, Hekmatnia Ali, Iraj Bijan, Nourian Mojgan
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Medicine and Family Physician, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2017 Feb 23;8:10. doi: 10.4103/2008-7802.200854. eCollection 2017.
Obesity is increasingly associated with nonalcoholic fatty liver disease (NAFLD) and weight loss through a combination of dietary modifications and increased physical activity is a primary goal of therapy in this disease. Therefore, this study was conducted to evaluate the effects of a lifestyle modification education on adiposity measures, physical activity, and total calorie intake in overweight and obese NAFLD patients.
During 8 weeks, 82 obese patients were randomly assigned into either an intervention group ( = 41) receiving a lifestyle modification education or to a control group ( = 41) receiving usual care. Total calorie intake, physical activity, and body composition indices were measured before and after the intervention.
Thirty-six patients in intervention group and 33 in control group completed the study. The analysis of body composition variables did not show any significant reduction for percent of body fat, abdominal circumference, waist to hip ratio, visceral fat area, age matched of body, and soft lean mass (SLM) of the trunk ( > 0.05). On the other hand, a significant reduction in weight, body mass index, mass of body fat (MBF), SLM, and MBF of the trunk was observed after 2 months of intervention compared to the controls ( < 0.05). A significant reduction was observed in total calorie intake of intervention group as compared to the control group. Physical activity status did not show any significant improvements after 2 months of intervention.
Our lifestyle modification education and its guidelines could be used in obese patients with NAFLD to improve their body composition measurements and to lose weight. This could result in significant long-term benefits in NAFLD patients.
肥胖与非酒精性脂肪性肝病（NAFLD）的关联日益密切，通过饮食调整和增加体育活动相结合来减轻体重是该疾病治疗的主要目标。因此，本研究旨在评估生活方式改变教育对超重和肥胖的NAFLD患者肥胖指标、身体活动和总热量摄入的影响。
在8周内，82名肥胖患者被随机分为接受生活方式改变教育的干预组（n = 41）或接受常规护理的对照组（n = 41）。在干预前后测量总热量摄入、身体活动和身体成分指标。
干预组36名患者和对照组33名患者完成了研究。身体成分变量分析显示，身体脂肪百分比、腹围、腰臀比、内脏脂肪面积、身体年龄匹配值和躯干软瘦质量（SLM）均无显著降低（P>0.05）。另一方面，与对照组相比，干预2个月后观察到体重、体重指数、身体脂肪质量（MBF）、SLM和躯干MBF显著降低（P<0.05）。与对照组相比，干预组的总热量摄入显著降低。干预2个月后，身体活动状况未显示出任何显著改善。
我们的生活方式改变教育及其指导方针可用于肥胖的NAFLD患者，以改善他们的身体成分测量并减轻体重。这可能会给NAFLD患者带来显著的长期益处。
