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杂环嘧啶支架的治疗潜力。

Therapeutic potential of heterocyclic pyrimidine scaffolds.

作者信息

Kumar Sanjiv, Narasimhan Balasubramanian

机构信息

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

出版信息

Chem Cent J. 2018 Apr 4;12(1):38. doi: 10.1186/s13065-018-0406-5.

Abstract

Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. The present review article aims to review the work reported on therapeutic potentials of pyrimidine scaffolds which are valuable for medical applications during new generation.

摘要

杂环化合物具有高度的结构多样性,并且已被证明作为治疗剂具有广泛的经济用途。对杂环化合物各种治疗潜力的全面研究证实了它们在疾病病理生理学中的巨大意义。杂环嘧啶核是脱氧核糖核酸遗传物质的重要碱基组成部分,具有多种生物活性。本综述文章旨在回顾关于嘧啶支架治疗潜力的报道工作,这些支架在新一代医学应用中具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/939f/5884769/fa8f4d0fe8a8/13065_2018_406_Fig1_HTML.jpg

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