Walker R W, Brochstein J A
Cornell University Medical College, New York, New York.
Neurol Clin. 1988 May;6(2):261-78.
The immunosuppressive agents that are an integral part of organ transplantation serve to protect grafts from rejection as well as to prevent or treat GVHD. They include CsA, corticosteroids, OKT3 monoclonal antibody, HDARA-C, azathioprine, and ATG. Of these, all but azathioprine and ATG have direct neurologic complications that are due to the drugs themselves and not just excessive immune suppression. With increasing success in solid organ and bone marrow transplantation and increasing patient survival, one can expect to see more patients who suffer neurologic toxicity.
作为器官移植不可或缺一部分的免疫抑制剂，用于保护移植物免受排斥反应以及预防或治疗移植物抗宿主病（GVHD）。它们包括环孢素A（CsA）、皮质类固醇、OKT3单克隆抗体、大剂量阿糖胞苷（HDARA-C）、硫唑嘌呤和抗胸腺细胞球蛋白（ATG）。在这些药物中，除了硫唑嘌呤和抗胸腺细胞球蛋白外，其他药物都有直接的神经并发症，这些并发症是由药物本身引起的，而不仅仅是过度免疫抑制导致的。随着实体器官和骨髓移植成功率的提高以及患者生存率的增加，可以预期会有更多患者出现神经毒性。
