State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 Gansu, China.
Chengdu Guibao Science and Technology Co., Ltd, Chengdu, 610041 Sichuan, China.
Org Lett. 2023 May 5;25(17):3007-3012. doi: 10.1021/acs.orglett.3c00790. Epub 2023 Apr 21.
The synthesis of benzo[]azepines using protonated aminating reagent (MsONHOTf) and alkynes through I-mediated [6 + 1] annulation reaction has been developed. This protocol features excellent functional group tolerance and mild reaction conditions and affords the benzo[]azepines in moderate to good yields under metal-free reaction conditions.
使用质子化的氨化试剂（MsONHOTf）和炔烃通过 I 介导的 [6 + 1] 环加成反应合成苯并[azepine]已经被开发出来。该方法具有优异的官能团耐受性和温和的反应条件，在无金属反应条件下以中等至良好的收率得到苯并[azepine]。
