Department of Internal Medicine, Womack Army Medical Center, Fort Bragg, NC 28310, USA.
Department of Clinical Investigation, Womack Army Medical Center, Fort Bragg, NC 28310, USA.
Biomark Med. 2019 Aug;13(12):1025-1033. doi: 10.2217/bmm-2019-0027. Epub 2019 Aug 6.
Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers. Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009-2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao-Scott χ tests measured associations between group characteristics. The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity. There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations.
我们的目标是评估可替宁切点在吸烟者和不吸烟者亚组中的意义。数据来自于参加国家健康和营养调查的 13357 名成年人（2009-2014 年）。采用受试者工作特征曲线分析确定最佳切点。Rao-Scott χ 检验衡量组间特征的关联。成年烟民血清可替宁的最佳切点为 3.63ng/ml（灵敏度为 96.7%；特异性为 93.0%）。该切点因性别和种族/民族而异。与既往研究相比，亚组切点存在显著差异。在可行的情况下，使用性别或种族/民族特异性切点更合适，可能有助于临床医生的建议。
