利用无创工具确定埃及慢性乙型肝炎患者的肝纤维化分期。
Determination of liver fibrosis stages in Egyptian chronic hepatitis B patients by a noninvasive tool.
机构信息
Department of Chemistry, Faculty of Science, Suez University, Suez, Egypt
Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
出版信息
Turk J Med Sci. 2019 Aug 8;49(4):1145-1150. doi: 10.3906/sag-1812-165.
BACKGROUND/AIM: Hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF). The prognosis and management of patients with chronic hepatitis B virus depend on the amount and progression of liver fibrosis. Angiopoietin-like protein 2 (Angptl2) is not only a chronic inflammatory mediator, but also a tissue-remodeling factor. The aim of this study is to explore the predictive value of Angptl2 in different fibrosis stages in patients chronically infected with HBV.
MATERIALS AND METHODS
Eighty patients with chronic HBV infection undergoing Fibroscan were included. Serum concentrations of Angptl2 were detected using a commercial ELISA kit.
RESULTS
Angptl2 levels were significantly associated with liver fibrosis stages (P = 0.02). The area under the curve (AUC) of Angptl2 for distinguishing patients who showed significant fibrosis (F2–F4) was70.2%. Angptl2 with fibrosis-4 (FIB-4) and Angptl2 with AST/platelets ratio (APRI) performed best with an AUC of 92.5%.
CONCLUSION
In patients with chronic HBV infection, Angptl2 level represents a potential biomarker independently associated with fibrosis stages. The combination of Angptl2 with FIB-4 or Angptl2 with APRI performed better than the existing models for diagnosing significant fibrosis.
背景/目的：乙型肝炎病毒（HBV）感染是肝纤维化（LF）的主要原因。慢性乙型肝炎病毒患者的预后和管理取决于肝纤维化的程度和进展。血管生成素样蛋白 2（Angptl2）不仅是一种慢性炎症介质，也是一种组织重塑因子。本研究旨在探讨 Angptl2 在慢性 HBV 感染患者不同纤维化分期中的预测价值。
材料和方法
纳入 80 例接受 Fibroscan 的慢性 HBV 感染患者。使用商业 ELISA 试剂盒检测血清 Angptl2 浓度。
结果
Angptl2 水平与肝纤维化分期显著相关（P = 0.02）。Angptl2 区分有显著纤维化（F2-F4）患者的曲线下面积（AUC）为 70.2%。Angptl2 联合纤维化-4（FIB-4）和 Angptl2 联合 AST/血小板比值（APRI）的 AUC 最佳，为 92.5%。
结论
在慢性 HBV 感染患者中，Angptl2 水平是与纤维化分期独立相关的潜在生物标志物。Angptl2 联合 FIB-4 或 Angptl2 联合 APRI 的表现优于现有用于诊断显著纤维化的模型。
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